A 33-year-old man is brought by ambulance to the emergency room after being a passenger in a motor vehicle accident. An empty bottle of whiskey was found in his front seat, and the patient admits to having been drinking all night. He has multiple lacerations and bruising on his face and scalp and a supportive cervical collar is placed. He is endorsing a significant headache and starts vomiting in the emergency room. His vitals, however, are stable, and he is transported to the CT scanner. While there, he states that he does not want to have a CT scan and asks to be released. What is the most appropriate course of action?

Explain to him that he is intoxicated and cannot make health care decisions, continue as planned

Have the patient fill the appropriate forms and discharge against medical advice

Release the patient as requested

A 25-year-old man comes to the physician for severe back pain. He describes the pain as shooting and stabbing. On a 10-point scale, he rates the pain as a 9 to 10. The pain started after he lifted a heavy box at work; he works at a supermarket and recently switched from being a cashier to a storekeeper. The patient appears to be in severe distress. Vital signs are within normal limits. On physical examination, the spine is nontender without paravertebral muscle spasms. Range of motion is normal. A straight-leg raise test is negative. After the physical examination has been completed, the patient asks for a letter to his employer attesting to his inability to work as a storekeeper. Which of the following is the most appropriate response?

I understand that you are uncomfortable, but the findings do not match the severity of your symptoms. Let's talk about the recent changes at your job.

“Yes. Since work may worsen your condition, I would prefer that you stay home a few days. I will write a letter to your employer to explain the situation.”

You say you are in severe pain. However, the physical examination findings do not suggest a physical problem that can be addressed with medications or surgery. I'd like to meet on a regular basis to see how you're doing.

The physical exam findings do not match your symptoms, which suggests a psychological problem. I would be happy to refer you to a mental health professional.

The physical exam findings suggest a psychological rather than a physical problem. But there is a good chance that we can address it with cognitive-behavioral therapy.

Two studies are reviewed for submission to an oncology journal. In Study A, a novel MRI technology is evaluated as a screening tool for ovarian cancer. The authors find that the mean survival time is 4 years in the control group and 10 years in the MRI-screened group. In Study B, cognitive behavioral therapy (CBT) and a novel antidepressant are used to treat patients with comorbid pancreatic cancer and major depression. Patients receiving the new drug are told that they are expected to have quick resolution of their depression, while those who do not receive the drug are not told anything about their prognosis. Which of the following describes the likely type of bias in Study A and Study B?

Lead time bias; Pygmalion effect

A 27-year-old woman is brought to the physician by her parents because they are concerned about her mood. They say that she has “not been herself” since the death of her friend, who was killed 3 weeks ago when the fighter jet he piloted was shot down overseas. She says that since the incident, she feels sad and alone. She reports having repeated nightmares about her friend's death. Her appetite has decreased, but she is still eating regularly and is otherwise able to take care of herself. She does not leave her home for any social activities and avoids visits from friends. She went back to work after taking 1 week off after the incident. Her vital signs are within normal limits. Physical examination shows no abnormalities. On mental status examination, she appears sad, has a full range of affect, and is cooperative. In addition to taking measures to evaluate this patient's anxiety, which of the following is the most appropriate statement by the physician at this time?

I understand that the sudden loss of your friend has affected you deeply. Sometimes in situations like yours, people have thoughts that life is not worth living; have you had such thoughts?

I can see that you have gone through a lot recently, but I think that your reaction is especially severe and has persisted for longer than normal. Would you be open to therapy or medication to help you manage better?

I am worried that you may be having an abnormally severe reaction to what is an understandably stressful event. I recommend attending behavioral therapy sessions to help you deal with this challenge.

Your grief over the loss of your friend appears to have a negative effect on your social and functional capabilities. I recommend starting antidepressants to help you deal with this challenge.

I'm so sorry, but the loss of loved ones is a part of life. Let's try to find better ways for you to deal with this event.

Cognitive biases in differential construction | Differential diagnosis

Anchoring Bias: Locking onto initial information (e.g., a prior diagnosis or a single symptom) and failing to adjust, even with new data.
Availability Heuristic: Overestimating the likelihood of diagnoses that are dramatic or easily recalled, like a recently seen case.
Confirmation Bias: Selectively gathering data that supports a suspected diagnosis while downplaying evidence that refutes it.
Premature Closure: Quickly accepting a diagnosis without fully verifying it or exploring all differential possibilities. A major source of error.

⭐ Cognitive errors are a leading cause of diagnostic failure. A key debiasing strategy is metacognition: deliberately asking "What else could this be?" and "What findings don't fit?"

The Usual Suspects - Rogues' Gallery of Biases

Bias	Description	Classic Example
Anchoring Bias	Over-relying on the initial piece of information (the "anchor") to make subsequent judgments.	A patient's chest pain is initially attributed to anxiety; subsequent ECG changes are downplayed.
Availability Heuristic	Overestimating the likelihood of diagnoses that are more easily recalled, often due to recent or vivid cases.	After seeing a rare case of vasculitis, a clinician diagnoses it in the next three patients with a rash.
Confirmation Bias	Tendency to search for, interpret, favor, and recall information that confirms pre-existing beliefs.	Ordering multiple imaging studies to confirm a suspected disc herniation while ignoring clinical signs of spinal infection.
Premature Closure	Accepting a diagnosis before it has been fully verified. The workup stops too soon.	Diagnosing a patient with gastroenteritis and discharging them, only for them to return with appendicitis.
Zebra Retreat	Backing away from a rare diagnosis when it is actually a strong possibility, due to fear of being wrong.	"When you hear hoofbeats, think of horses, not zebras." Dismissing a classic presentation of a rare disease.

Debiasing Techniques - Cognitive CPR

📌 Cognitive CPR is a metacognitive strategy to reduce diagnostic error. It involves a structured approach to decision-making, forcing a pause to challenge initial impressions and assumptions.

Cognitive Awareness: Acknowledge high-risk situations (e.g., fatigue, complex cases).
Pause & Reflect: Actively consider "What else could this be?". Use checklists.
Reframe & Resample: Challenge the primary diagnosis. Seek disconfirming evidence.

⭐ Metacognition, or "thinking about one's own thinking," is the cornerstone of effective debiasing. Simply being aware of biases is insufficient without active reflection and corrective strategies.

High‑Yield Points - ⚡ Biggest Takeaways

Anchoring bias is clinging to an initial impression, even with conflicting data.

Availability heuristic overestimates the likelihood of diagnoses that are easily recalled.

Confirmation bias involves seeking evidence that supports a favored diagnosis while ignoring contradictory information.

Premature closure is accepting a diagnosis before it has been fully verified, leading to missed diagnoses.

Actively considering alternatives and using checklists can mitigate these biases.