Urogenital system development US Medical PG Practice Questions and MCQs
Practice US Medical PG questions for Urogenital system development. These multiple choice questions (MCQs) cover important concepts and help you prepare for your exams.
Urogenital system development US Medical PG Question 1: During the third week of development, the blastocyst undergoes a variety of differentiation processes responsible for the formation of the gastrula and, eventually, the embryo. This differentiation creates cell lineages that eventually become a variety of body systems. What cell lineage, present at this date, is responsible for the formation of the liver?
- A. Neuroectoderm
- B. Syncytiotrophoblasts
- C. Ectoderm
- D. Endoderm (Correct Answer)
- E. Mesoderm
Urogenital system development Explanation: ***Endoderm***
- The **endoderm** is one of the three primary germ layers that develops during gastrulation and is responsible for forming the lining of the **gastrointestinal tract** and associated organs, including the **liver** and pancreas.
- Liver development begins from an outgrowth of the **foregut endoderm**, which differentiates into hepatocytes and bile duct cells, forming the hepatic parenchyma.
*Neuroectoderm*
- **Neuroectoderm** is a specialized part of the ectoderm that gives rise to the entire **nervous system**, including the brain, spinal cord, and peripheral nerves.
- It does not contribute to the formation of visceral organs like the liver.
*Syncytiotrophoblasts*
- **Syncytiotrophoblasts** are a layer of the **trophoblast** that form part of the placenta, specifically involved in hormone production and nutrient exchange between the mother and fetus.
- They are part of the supporting structures for pregnancy and do not contribute to the embryonic germ layers or organ formation within the embryo itself.
*Ectoderm*
- The **ectoderm** is the outermost germ layer and gives rise to the **epidermis of the skin**, hair, nails, nervous system, and sensory organs.
- While it forms the outer coverings and nervous system, it does not directly form internal organs like the liver.
*Mesoderm*
- The **mesoderm** is the middle germ layer, responsible for forming **muscle**, **bone**, connective tissue, the circulatory system, kidneys, and gonads.
- While mesoderm contributes supporting structures to the liver (blood vessels, connective tissue, hematopoietic cells), the **hepatic parenchyma** (hepatocytes and bile ducts) is derived from the endoderm, making endoderm the primary cell lineage responsible for liver formation.
Urogenital system development US Medical PG Question 2: A 31-year-old man presents for his annual physical exam. The physician fails to palpate a ductus deferens on the left side. An ultrasound confirms absence of the left ductus deferens and further reveals absence of the left epididymis, seminal vesicle, and kidney. Spermogram and reproductive hormones panel are within normal limits. Left-sided agenesis of an embryonic anlage is suspected. Which two structures are connected by this anlage during embryogenesis?
- A. Metanephros and coelom
- B. Mesonephros and coelom
- C. Pronephros and cloaca
- D. Mesonephros and cloaca (Correct Answer)
- E. Pronephros and coelom
Urogenital system development Explanation: ***Mesonephros and cloaca***
- The **mesonephros** forms the **mesonephric (Wolffian) duct**, which connects to the **cloaca**.
- In males, this duct gives rise to the **epididymis**, **vas deferens**, **seminal vesicles**, and **ureteric bud** (which forms the kidney collecting system). The simultaneous absence of the kidney, epididymis, and seminal vesicle indicates a defect in this developmental pathway.
*Metanephros and coelom*
- The **metanephros** is a later stage of kidney development, forming the definitive kidney parenchyma, but it does **not connect directly to the coelom**.
- Its excretory ducts develop from an interaction with the ureteric bud (derived from the mesonephric duct), not directly from the coelom.
*Mesonephros and coelom*
- While the **mesonephros** develops within the intermediate mesoderm adjacent to the **coelom**, its primary connection relevant to these structures is to the cloaca via the mesonephric duct.
- The **coelom** is the primitive body cavity, and direct connections to the adult reproductive/urinary tracts in this manner are not embryologically accurate for this defect.
*Pronephros and cloaca*
- The **pronephros** is a transient, non-functional embryonic kidney structure that degenerates early in development and does **not form the definitive male reproductive or urinary structures** seen here.
- Its connection to the cloaca is not as direct or as developmentally critical for the structures described in the case.
*Pronephros and coelom*
- Similar to the previous option, the **pronephros** is an early and transient structure.
- It does **not develop into the adult genitourinary structures** affected in this patient, and its relationship with the coelom is not the key to understanding this specific congenital anomaly.
Urogenital system development US Medical PG Question 3: A pregnant woman gives birth to her 1st child at the family farm. After delivery, the assisting midwife notices a triangular defect in the lower anterior abdominal wall of the baby. She clamps the umbilical cord with a cloth and urges the family to seek immediate medical care at the nearest hospital. Upon admission, the attending pediatrician further notices an open bladder plate with an exposed urethra, a low set umbilicus, an anteriorly displaced anus, and an inguinal hernia. No omphalocele is noted. The external genitalia is also affected. On physical exam, a shortened penis with a pronounced upward curvature and the urethral opening along the dorsal surface are also noted. What is the most likely diagnosis?
- A. Posterior urethral valves
- B. Bladder exstrophy (Correct Answer)
- C. Body stalk anomaly
- D. Cloacal exstrophy
- E. Urachal cyst
Urogenital system development Explanation: ***Bladder exstrophy***
- The findings of a **triangular defect in the lower anterior abdominal wall**, an **open bladder plate with an exposed urethra**, a **low set umbilicus**, an **anteriorly displaced anus**, and affected external genitalia including a **shortened penis with pronounced upward curvature** (epispadias) are pathognomonic for **bladder exstrophy**.
- This condition results from a developmental failure of the infraumbilical abdominal wall and anterior bladder wall to close, leading to the bladder being open to the outside and often associated with epispadias due to abnormal tubercle development.
*Posterior urethral valves*
- This condition is characterized by **obstructive membranes within the posterior urethra of male infants**, leading to urinary obstruction and hydronephrosis.
- It does not involve an open bladder plate or abdominal wall defect, and the external genitalia are typically normal save for potential complications of urinary outflow obstruction.
*Body stalk anomaly*
- This is a severe congenital malformation characterized by **defects of the abdominal wall, thorax, and limbs**, with the fetus usually attached to the placenta by a short, thick umbilical cord.
- While it involves abdominal wall defects, it does not typically present with an exposed bladder plate and exposed urethra as the primary defect, nor is it specifically associated with epispadias.
*Cloacal exstrophy*
- Cloacal exstrophy is a more severe and complex defect than bladder exstrophy, involving the **exstrophy of both the bladder and a portion of the hindgut (intestine)**, often with omphalocele.
- The absence of an **omphalocele** and the specific description of an **open bladder plate** without obvious intestinal exposure make bladder exstrophy a more likely diagnosis.
*Urachal cyst*
- An urachal cyst is a **remnant of the allantois** that persists as a cystic structure between the bladder and the umbilicus, often presenting as a palpable mass or a discharge from the umbilicus.
- It does not involve an open abdominal wall defect, exposed bladder, or epispadias, which are central to the patient's presentation.
Urogenital system development US Medical PG Question 4: A 27-year-old female in her 20th week of pregnancy presents for a routine fetal ultrasound screening. An abnormality of the right fetal kidney is detected. It is determined that the right ureteropelvic junction has failed to recanalize. Which of the following findings is most likely to be seen on fetal ultrasound:
- A. Renal cysts
- B. Duplicated ureter
- C. Bilateral renal agenesis
- D. Pelvic kidney
- E. Unilateral hydronephrosis (Correct Answer)
Urogenital system development Explanation: ***Unilateral hydronephrosis***
- Failure of the **ureteropelvic junction (UPJ)** to recanalize leads to an obstruction of urine flow from the **renal pelvis** into the ureter.
- This obstruction causes a buildup of urine in the renal pelvis and calyces, a condition known as **hydronephrosis**, which will be unilateral as only the right kidney is affected.
*Renal cysts*
- **Renal cysts** are typically associated with conditions like polycystic kidney disease or multicystic dysplastic kidney, which involve abnormal development of renal parenchyma, not specifically a UPJ obstruction.
- While hydronephrosis can sometimes lead to cystic changes if severe and prolonged, in the initial stages of a UPJ obstruction detected on fetal ultrasound, **hydronephrosis** itself is the primary and most likely finding.
*Duplicated ureter*
- A **duplicated ureter** is a distinct congenital anomaly involving the formation of two ureters draining a single kidney or separate renal moieties.
- It does not directly result from the failure of **ureteropelvic junction recanalization**.
*Bilateral renal agenesis*
- **Bilateral renal agenesis** means both kidneys failed to develop, which would lead to severe oligohydramnios and is incompatible with sustained fetal life.
- The question describes an abnormality only in the **right kidney**, making bilateral agenesis incorrect.
*Pelvic kidney*
- A **pelvic kidney** (renal ectopia) occurs when the kidney fails to ascend from the pelvis to its normal lumbar position.
- This is a positional anomaly and is not directly caused by a failure of **ureteropelvic junction recanalization**.
Urogenital system development US Medical PG Question 5: A newborn infant with karyotype 46, XY has male internal and external reproductive structures. The lack of a uterus in this infant can be attributed to the actions of which of the following cell types?
- A. Granulosa
- B. Theca
- C. Leydig
- D. Reticularis
- E. Sertoli (Correct Answer)
Urogenital system development Explanation: ***Sertoli***
- **Sertoli cells** in the fetal testis produce **Anti-Müllerian Hormone (AMH)**, which is crucial for the regression of the **Müllerian ducts**.
- The **Müllerian ducts** (also called paramesonephric ducts) would otherwise develop into the uterus, fallopian tubes, and upper vagina in the female fetus. In a male fetus, AMH from Sertoli cells causes these structures to degenerate, leading to the absence of a uterus.
*Granulosa*
- **Granulosa cells** are found in the ovarian follicles of females and are involved in **estrogen synthesis** and support of oocyte development.
- They do not play a role in Müllerian duct regression; in fact, the absence of AMH in female fetuses allows the Müllerian ducts to develop.
*Theca*
- **Theca cells** are also found in the ovarian follicles and are responsible for producing **androgens** (which are then converted to estrogen by granulosa cells).
- Like granulosa cells, theca cells are involved in ovarian function and estrogen production, not in the regression of Müllerian ducts.
*Leydig*
- **Leydig cells** are located in the interstitium of the testes and are responsible for producing **androgens** (primarily testosterone) in response to luteinizing hormone (LH).
- Testosterone from Leydig cells promotes the development of the **Wolffian ducts** (which form male internal reproductive structures like the epididymis, vas deferens, and seminal vesicles), but it does not directly cause the regression of the Müllerian ducts.
*Reticularis*
- The **zona reticularis** is the innermost layer of the adrenal cortex and produces **adrenal androgens**.
- While adrenal androgens play a role in puberty and certain endocrine conditions, they are not involved in the differentiation of fetal reproductive tracts or the regression of Müllerian ducts.
Urogenital system development US Medical PG Question 6: A child is in the nursery one day after birth. A nurse notices a urine-like discharge being expressed through the umbilical stump. What two structures in the embryo are connected by the structure that failed to obliterate during the embryologic development of this child?
- A. Kidney - large bowel
- B. Liver - umbilical vein
- C. Bladder - small bowel
- D. Pulmonary artery - aorta
- E. Bladder - umbilicus (Correct Answer)
Urogenital system development Explanation: ***Bladder - umbilicus***
- A **urine-like discharge** from the umbilical stump indicates a **patent urachus**, which is the embryonic remnant of the allantois.
- The **allantois** (which becomes the urachus) is an embryonic structure that connects the **fetal bladder** to the **umbilicus** during development.
- Normally, the allantois obliterates after birth to form the **median umbilical ligament**, but failure to obliterate results in a patent urachus allowing urine to discharge through the umbilicus.
*Kidney - large bowel*
- These two structures are not directly connected by an obliterating embryonic structure relevant to urine discharge from an umbilical stump.
- The kidneys form urine, and the large bowel is part of the digestive tract, with no direct embryonic communication to the umbilicus for urine expression.
*Liver - umbilical vein*
- The umbilical vein connects the **placenta to the fetal liver** (and ductus venosus) to transport oxygenated blood, not urine.
- Failure of the umbilical vein to obliterate would result in a patent umbilical vein, typically presenting as a vascular anomaly, not urine discharge.
*Pulmonary artery - aorta*
- These structures are connected by the **ductus arteriosus** in fetal circulation, bypassing the pulmonary circulation.
- While important for fetal development, a patent ductus arteriosus (PDA) is a cardiovascular anomaly and would not manifest as urine discharge from the umbilical stump.
*Bladder - small bowel*
- While both structures are involved in waste elimination, there is no normal embryonic structure directly connecting the bladder and small bowel that obliterates to prevent urine discharge from the umbilicus.
- An abnormal connection between the bladder and bowel would typically involve a **fistula** and present with stool in urine or urine in stool, not umbilical discharge.
Urogenital system development US Medical PG Question 7: A 17-year-old girl is being evaluated for primary amenorrhea. A pelvic ultrasound shows no uterus, fallopian tubes, or ovaries, despite having normal external sexual organs. On physical examination, there is no axillary or pubic hair, and breast development is normal. The laboratory tests show evidence of increased serum testosterone with normal conversion to dihydrotestosterone (DHT) and increased luteinizing hormone (LH). What is the karyotype of this patient?
- A. 47, XXY
- B. 45, X0
- C. 46, XX
- D. 46, XY (Correct Answer)
- E. 47, XXX
Urogenital system development Explanation: ***46, XY***
- This patient presents with **complete androgen insensitivity syndrome (CAIS)**. Despite having a **46, XY karyotype** (genetically male), the body's cells are unable to respond to androgens.
- While genetically male, the lack of androgen action prevents the development of male internal and external genitalia, leading to the development of **female external genitalia** and **normal breast development** due to estrogen action (from androgen aromatization) but no uterus, fallopian tubes, or ovaries. The **absence of axillary and pubic hair** (secondary sex characteristics dependent on androgens) further supports CAIS, along with high testosterone and LH.
*47, XXY*
- This karyotype corresponds to **Klinefelter syndrome**, a condition in which individuals are genetically male with an extra X chromosome.
- Individuals with Klinefelter syndrome typically present with **hypogonadism**, **gynecomastia**, and are phenotypically male, often with small testes and infertility. They would not present with female external genitalia or absent internal female organs as described.
*45, X0*
- This karyotype describes **Turner syndrome**, characterized by the absence of one X chromosome, typically resulting in a female phenotype.
- Patients with Turner syndrome usually present with **primary amenorrhea**, **streak gonads**, **short stature**, and **lack of breast development** (due to ovarian failure), which contradicts the normal breast development seen in this patient.
*46, XX*
- This is the normal female karyotype. A patient with this karyotype would typically have **normal female internal and external genitalia**, including a uterus, fallopian tubes, and ovaries.
- The absence of a uterus, fallopian tubes, and ovaries in this patient, along with normal breast development but absent axillary/pubic hair, rules out a normal female karyotype.
*47, XXX*
- This karyotype refers to **Triple X syndrome**, which typically results in a female phenotype.
- Women with Triple X syndrome are often phenotypically normal and fertile, although some may experience **learning difficulties** or **mild developmental delays**. They would generally have **normal female internal and external reproductive organs**, which is contrary to the findings in this case.
Urogenital system development US Medical PG Question 8: A male newborn is born at 37 weeks' gestation after spontaneous vaginal delivery. The mother had no prenatal care. Physical examination shows a urethral opening on the dorsal aspect of the penis, 4 mm proximal to the glans. There is a 3-cm defect in the midline abdominal wall superior to the pubic symphysis with exposure of moist, erythematous mucosa. Which of the following is the most likely underlying cause of this patient's findings?
- A. Abnormal development of the gubernaculum
- B. Persistence of the urogenital membrane
- C. Failed fusion of the urethral folds
- D. Incomplete union of the labioscrotal swellings
- E. Malpositioning of the genital tubercle (Correct Answer)
Urogenital system development Explanation: ***Malpositioning of the genital tubercle***
- This condition describes **epispadias** (urethral opening on the dorsal aspect) and **bladder exstrophy** (abdominal wall defect with exposed bladder mucosa), which are frequently co-occurring and caused by a **ventral displacement of the genital tubercle**.
- A defect in the **abdominal wall closure** allows the bladder to remain exposed, and the abnormal positioning of the genital tubercle leads to an improperly formed urethra.
*Abnormal development of the gubernaculum*
- The gubernaculum is crucial for **testicular descent**; abnormal development would typically lead to **cryptorchidism** (undescended testes).
- It does not explain the urethral opening on the dorsal penis or the abdominal wall defect.
*Persistence of the urogenital membrane*
- Persistent urogenital membrane typically results in conditions like an **imperforate hymen** in females or **urogenital sinus anomalies**, but not epispadias or bladder exstrophy.
- This membrane normally ruptures, creating the definitive openings for the urethra and vagina.
*Failed fusion of the urethral folds*
- Failed fusion of the urethral folds in males can lead to **hypospadias**, where the urethral opening is on the **ventral** aspect of the penis.
- It does not account for the **dorsal urethral opening (epispadias)** described or the associated bladder exstrophy.
*Incomplete union of the labioscrotal swellings*
- Incomplete union of the labioscrotal swellings in males results in **bifid scrotum** or **hypospadias**.
- This doesn't explain the characteristic dorsal urethral defect of epispadias or the large abdominal wall defect associated with bladder exstrophy.
Urogenital system development US Medical PG Question 9: A 23-year-old woman, gravida 2, para 1, at 26 weeks gestation comes to the physician for a routine prenatal visit. Physical examination shows a uterus consistent in size with a 26-week gestation. Fetal ultrasonography shows a male fetus with a thick band constricting the right lower arm; the limb distal to the constrictive band cannot be visualized. The most likely condition is an example of which of the following embryological abnormalities?
- A. Agenesis
- B. Disruption (Correct Answer)
- C. Aplasia
- D. Deformation
- E. Malformation
Urogenital system development Explanation: ***Disruption***
- A **disruption** is a morphological defect of an organ or a larger body region resulting from an **extrinsic breakdown** of a previously normal developmental process.
- The **amniotic band syndrome**, causing the constricting band and absent distal limb, is a classic example of disruption due to **amniotic bands** entrapping fetal parts.
*Agenesis*
- **Agenesis** refers to the complete **absence of an organ** due to the absence of the primordial tissue from which it develops.
- In this case, the limb was initially present but was subsequently damaged, which is not agenesis.
*Aplasia*
- **Aplasia** refers to the complete **absence of an organ** when the primordial tissue was present but failed to develop.
- This differs from the scenario where a previously normally developing structure is destroyed by an extrinsic factor (disruption).
*Deformation*
- A **deformation** is an abnormality in form or position of a body part caused by **mechanical forces**, usually occurring in later fetal stages.
- Examples include clubfoot due to intrauterine compression, but it does not involve the intrinsic destruction of tissue observed here.
*Malformation*
- A **malformation** is a **primary defect** in the development of an organ or tissue due to an intrinsic abnormal developmental process.
- Examples include **cleft lip** or congenital heart defects; it is not due to an external disruptive force.
Urogenital system development US Medical PG Question 10: A 22-year-old G2P1 female presents to the clinic at the beginning of her third trimester for a fetal ultrasound. The sonographer is unable to visualize any of the structures arising from the mesonephric duct in the female fetus. This infant is at risk for malformation of which of the following?
- A. Fallopian tubes
- B. Upper 1/3 of vagina
- C. Uterus
- D. No malformation would be expected (Correct Answer)
- E. Lower 2/3 of vagina
Urogenital system development Explanation: ***No malformation would be expected***
- In females, structures originating from the **mesonephric duct** (Wolffian duct) normally **regress** due to the absence of testosterone.
- The female reproductive tract develops from the **paramesonephric duct** (Müllerian duct), which differentiates into the fallopian tubes, uterus, and upper vagina.
*Fallopian tubes*
- The **fallopian tubes** develop from the **paramesonephric (Müllerian) duct**, not the mesonephric duct.
- Therefore, non-visualization of mesonephric duct structures would not affect their development.
*Upper 1/3 of vagina*
- The **upper 1/3 of the vagina** also develops from the **paramesonephric (Müllerian) duct**.
- Its formation is independent of the mesonephric duct.
*Uterus*
- The **uterus** originates from the fusion of the two **paramesonephric (Müllerian) ducts**.
- Its development is not dependent on mesonephric duct structures.
*Lower 2/3 of vagina*
- The **lower 2/3 of the vagina** develops from the **urogenital sinus**, which is distinct from both the mesonephric and paramesonephric ducts.
- Thus, it would not be affected by non-development or non-visualization of mesonephric duct structures.
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