Post-Traumatic Stress Disorder

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PTSD Overview - Trauma's Lingering Shadow

  • Develops post-exposure to actual/threatened death, serious injury, or sexual violence (Criterion A).
  • Trauma Exposure Types:
    • Direct experience
    • Witnessing in person
    • Learning of trauma to close ones (violent/accidental)
    • Repeated/extreme exposure to aversive details (e.g., first responders)
  • Core DSM-5 Symptom Clusters:
    • B (Intrusion): Flashbacks, nightmares, distressing memories.
    • C (Avoidance): Of trauma-related thoughts, feelings, reminders.
    • D (Negative Cognitions/Mood): Amnesia, negative beliefs, detachment, anhedonia.
    • E (Arousal/Reactivity): Hypervigilance, exaggerated startle, irritability, sleep issues.

⭐ Symptoms must last for >1 month for a PTSD diagnosis, distinguishing it from Acute Stress Disorder. oka

Etiology & Risks - Seeds of Distress

  • Trauma Exposure: Essential. Severity, duration, and nature of event(s) are critical.
    • Includes direct experience, witnessing, learning of trauma to loved ones, or repeated exposure to aversive details (e.g., first responders).
  • Risk Factors: Multifactorial, influencing vulnerability and resilience.
    • Pre-Traumatic: Female gender, prior trauma, pre-existing psychiatric conditions, ↓socioeconomic status, genetic predisposition, early life adversity.
    • Peri-Traumatic: Severity of trauma (dose-response relationship), perceived life threat, physical injury, interpersonal violence (especially if perpetrated by caregiver), dissociation during trauma.
    • Post-Traumatic: Lack of social support, ongoing life stressors, maladaptive coping strategies, subsequent traumatic events.
  • Neurobiology: Complex interplay of brain circuits and stress systems.

    ⭐ Key neurobiological changes involve an overactive amygdala (fear response), underactive medial prefrontal cortex (mPFC) (emotional regulation), and altered hippocampal function (memory).

    • Hypothalamic-Pituitary-Adrenal (HPA) axis dysregulation (e.g., altered cortisol levels).
    • Neurotransmitter imbalances (e.g., ↑Norepinephrine, ↓Serotonin, altered GABA & glutamate). Brain regions and fear responses in PTSD

Diagnosis & DDx - Pinpointing PTSD

  • DSM-5 Criteria: Exposure to trauma; Symptoms from 4 clusters (Intrusion, Avoidance, Negative Cognitions/Mood, Arousal/Reactivity); Duration >1 month; Significant distress/impairment.
  • Key Assessment Tools:
    • Clinician-Administered PTSD Scale (CAPS-5) - Gold standard
    • PTSD Checklist for DSM-5 (PCL-5) - Self-report
  • Differential Diagnosis:
    • Acute Stress Disorder (ASD)
    • Adjustment Disorder (stressor severity differs)
    • Anxiety Disorders (GAD, Panic)
    • Depressive Disorders (MDD)
    • OCD (nature of intrusions differs)
    • Malingering/Factitious

Acute Stress Disorder (ASD) symptoms last from 3 days to 1 month post-trauma; if symptoms persist beyond 1 month or develop later, it's PTSD.

Treatment Modalities - Paths to Recovery

  • Primary Goals: Symptom reduction, functional improvement, enhanced quality of life.

  • Combined Approach: Psychotherapy and pharmacotherapy often yield best outcomes.

  • Psychotherapy (First-line & Cornerstone):

    • Trauma-Focused CBT (TF-CBT): Gold standard. Targets maladaptive thoughts & behaviors.
    • Eye Movement Desensitization & Reprocessing (EMDR): Uses bilateral stimulation (e.g., eye movements) while processing trauma.
    • Prolonged Exposure (PE): Gradual, systematic confrontation with trauma memories/cues.
    • Cognitive Processing Therapy (CPT): Identifies & challenges unhelpful trauma-related beliefs.
  • Pharmacotherapy:

    • SSRIs (First-line):
      • Sertraline (50-200 mg/day).
      • Paroxetine (20-60 mg/day).
    • SNRIs (e.g., Venlafaxine): Second-line option.
    • Prazosin: Effective for nightmares and sleep disturbances.
    • ⚠️ Benzodiazepines: Generally avoided due to risks of dependence and symptom worsening.

⭐ First-line pharmacological treatments for PTSD are SSRIs (Sertraline, Paroxetine); Prazosin is used for nightmares.

High‑Yield Points - ⚡ Biggest Takeaways

  • PTSD follows traumatic event exposure; symptoms must last >1 month.
  • Core features: Intrusion (flashbacks, nightmares), Avoidance of reminders, Negative alterations in cognitions/mood, and Altered arousal/reactivity.
  • Differentiate from Acute Stress Disorder (symptoms 3 days to 1 month).
  • SSRIs (Sertraline, Paroxetine) are first-line drugs; CBT/EMDR are key psychotherapies.
  • Prazosin specifically targets and reduces nightmares.
  • Frequently comorbid with depression, anxiety disorders, and substance abuse.

Practice Questions: Post-Traumatic Stress Disorder

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Flashcards: Post-Traumatic Stress Disorder

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_____ disorder is characterized by symptoms of PTSD that last between 3 days and 1 month (duration)

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_____ disorder is characterized by symptoms of PTSD that last between 3 days and 1 month (duration)

Acute stress

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