OCD Spectrum Disorders

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Overview of OCD Spectrum - Obsession's Cousins

  • Group of disorders related to OCD, sharing features of repetitive thoughts or behaviors.
  • Core features:
    • Preoccupations (intrusive thoughts) or repetitive behaviors (e.g., body-focused repetitive behaviors [BFRBs], rituals).
    • Cause significant distress or functional impairment.
  • Distinction from classic OCD:
    • Focus often on perceived flaws (e.g., Body Dysmorphic Disorder), body-focused actions (e.g., Trichotillomania, Excoriation Disorder), or acquiring/saving items (e.g., Hoarding Disorder).
    • Not primarily driven by typical obsessions and compulsions seen in OCD.

⭐ Insight in OCD spectrum disorders can range from good to absent/delusional, significantly impacting treatment adherence and prognosis.

Body Dysmorphic Disorder (BDD) - Mirror, Mirror Misery

  • Preoccupation: ≥1 perceived defects/flaws in physical appearance; not observable or slight to others.
  • Repetitive Behaviors (compulsions) or mental acts:
    • Mirror checking, excessive grooming, skin picking, reassurance seeking.
    • Comparing appearance to others.
  • Causes clinically significant distress or impairment.
  • Insight specifiers: With good/fair insight, poor insight, or absent insight/delusional beliefs.
  • Muscle dysmorphia: Subtype; preoccupation that body build is too small or insufficiently muscular.
  • Common concerns: Skin (e.g., acne, scars), hair (e.g., thinning), nose (e.g., size, shape). Body Dysmorphic Disorder

⭐ BDD is associated with high rates of suicidal ideation and attempts, often comparable to or exceeding those in major depressive disorder.

  • Treatment: SSRIs (often higher doses), Cognitive Behavioral Therapy (CBT) with Exposure and Response Prevention (ERP).

Hoarding, TTM, & Excoriation - Clutter & Compulsions

  • Hoarding Disorder:

    • Persistent difficulty discarding items, regardless of value → clutter.
    • Strong urge to save; distress with discarding.
    • Causes significant distress/impairment. Not due to other conditions.
    • Specifiers: w/ excessive acquisition; insight (good/fair, poor, absent/delusional).
  • Body-Focused Repetitive Behaviors (BFRBs):

    • Trichotillomania (TTM): Recurrent hair pulling → hair loss (alopecia).
    • Excoriation Disorder: Recurrent skin picking → skin lesions/scars.
    • Common: Repeated attempts to stop; significant distress/impairment.
    • 📌 BFRBs: Recurrent, Unsuccessful attempts to stop, Body damage, Significant distress (RUBS).
    FeatureTrichotillomania (TTM)Excoriation Disorder
    Primary ActionHair pullingSkin picking
    Common SitesScalp, eyebrows, eyelashesFace, arms, hands
    AssociatedExamining root, twirling, trichophagiaSqueezing, biting, examining skin

⭐ Hoarding disorder often has poor insight & is ego-syntonic, unlike typically ego-dystonic OCD, complicating treatment.

Shared Pathophysiology & Treatment - Brain Circuits & Fixes

  • Core Pathophysiology:
    • Brain Circuits: Dysregulation in Cortico-Striato-Thalamo-Cortical (CSTC) pathways. Key areas: Orbitofrontal Cortex (OFC), Anterior Cingulate Cortex (ACC), Striatum.
    • Neurotransmitters: Primarily ↓ Serotonin (5-HT); Dopamine (DA) & Glutamate also implicated.
  • Treatment Pillars:
    • Pharmacotherapy:
      • SSRIs: First-line (e.g., Fluoxetine, Sertraline). Often require higher doses (e.g., Fluoxetine up to 80mg/day) and 10-12 weeks for response.
      • Clomipramine: Potent TCA, effective alternative.
      • Augmentation: Low-dose antipsychotics (e.g., Risperidone) for treatment-resistant OCD.
    • Psychotherapy:
      • Cognitive Behavioral Therapy (CBT) with Exposure and Response Prevention (ERP).
      • Habit Reversal Training (HRT) for Body-Focused Repetitive Behaviors (BFRBs).

    ⭐ CBT with Exposure and Response Prevention (ERP) is the most effective psychotherapeutic modality for OCD.

    • Neuromodulation: Deep Brain Stimulation (DBS) for severe, refractory cases.

Brain circuits involved in OCD

High‑Yield Points - ⚡ Biggest Takeaways

  • OCD: Characterized by obsessions (intrusive thoughts) and/or compulsions (repetitive acts); often ego-dystonic.
  • PANDAS: Sudden OCD/tic onset in children post-streptococcal infection.
  • Hoarding Disorder: Persistent difficulty discarding items, leading to clutter.
  • Body Dysmorphic Disorder (BDD): Preoccupation with perceived physical flaws.
  • Trichotillomania (hair-pulling) & Excoriation (skin-picking) are body-focused repetitive behaviors.
  • OCD Treatment: SSRIs (high doses), CBT (ERP). Clomipramine also effective.

Practice Questions: OCD Spectrum Disorders

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Body dysmorphic disorder can be associated with all except

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Flashcards: OCD Spectrum Disorders

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Persons having OCD often exhibit abnormal rates of metabolic activity in the _____ lobe and the basal ganglia of the brain

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Persons having OCD often exhibit abnormal rates of metabolic activity in the _____ lobe and the basal ganglia of the brain

frontal

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