Bulimia Nervosa

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Introduction - Binge-Purge Cycle Basics

  • Definition: Recurrent episodes of binge eating (large food amount, loss of control) AND recurrent inappropriate compensatory behaviors (e.g., vomiting, laxatives, fasting, excessive exercise) to prevent weight gain.
    • Occurs at least once a week for 3 months.
    • Self-evaluation is unduly influenced by body shape/weight.
  • Epidemiology:
    • Prevalence: ~1-1.5% in young women; F:M ratio ~10:1.
    • Age of onset: Late adolescence/early adulthood.
    • Indian context: Underreported; prevalence may be similar to Western countries in urban settings. Bulimia Nervosa: Binge-Purge Cycle Diagram

⭐ Bulimia Nervosa often co-occurs with mood and anxiety disorders, particularly depression and borderline personality disorder (Cluster B).

Diagnosis - Spotting the Signs

DSM-5 Diagnostic Criteria:

CriterionDescription
ARecurrent binge eating (large amount, loss of control)
BRecurrent inappropriate compensatory behaviors (purging/non)
CBoth ≥ once/week for 3 months
DSelf-worth tied to body shape/weight
ENot during Anorexia Nervosa
  • Purging: Vomiting, laxatives, diuretics.
  • Non-purging: Fasting, excessive exercise.

Key Physical Signs:

  • Russell's sign: Knuckle calluses (self-induced vomiting).
  • Dental enamel erosion (lingual surfaces).
  • Parotid gland enlargement (non-tender, bilateral).
  • Electrolyte imbalance (e.g., ↓K+, metabolic alkalosis).
  • Facial petechiae, subconjunctival hemorrhages (vomiting strain).

Russell's sign on hand knuckles

Psychological Features:

  • Intense fear of weight gain; body shape/weight preoccupation.
  • Distorted body image.
  • Shame, guilt, secrecy about eating.
  • Impulsivity, mood lability.

⭐ Russell's sign (knuckle calluses) indicates self-induced vomiting.

Complications - Body Under Siege

Bulimia Nervosa's (BN) recurrent purging (vomiting, laxatives, diuretics) causes severe multi-systemic damage.

  • Metabolic:
    • Hypokalemia ($K⁺ < \textbf{3.5} mEq/L$) - critical cardiac risk!
    • Hyponatremia ($Na⁺ < \textbf{135} mEq/L$)
    • Metabolic alkalosis (vomiting) or acidosis (laxative abuse)
  • Dental:
    • Enamel erosion (perimylolysis, especially lingual surfaces)
    • Increased dental caries, periodontitis
    • Dental erosion from bulimia nervosa
  • Gastrointestinal (GI):
    • Esophagitis, Mallory-Weiss tears (esophageal)
    • Salivary gland hypertrophy (sialadenosis, "chipmunk facies")
    • Laxative dependence, chronic constipation
  • Cardiovascular:
    • Arrhythmias (often due to hypokalemia)
    • Cardiomyopathy (chronic ipecac use)
  • Endocrine & Renal:
    • Menstrual irregularities (amenorrhea, oligomenorrhea)
    • Renal dysfunction, electrolyte wasting

⭐ Hypokalemia ($K⁺ < \textbf{3.5} mEq/L$) is a common, potentially life-threatening complication in BN, primarily from purging behaviors.

Management - Path to Recovery

Multimodal: Psychotherapy, pharmacotherapy, nutritional rehabilitation. Manage medical complications.

  • Psychotherapy:
    • CBT-BN: First-line.
    • IPT (Interpersonal Psychotherapy).
  • Pharmacotherapy:
    • SSRIs: Fluoxetine 60mg/day (FDA approved).
    • Other antidepressants considered.
  • Nutritional Rehabilitation: Essential for healthy eating.
  • Medical Complications: Address electrolyte imbalance, dental issues.

⭐ Cognitive Behavioral Therapy tailored for Bulimia Nervosa (CBT-BN) is the most evidence-based psychotherapy.

  • Stepped-Care Model:

Differentials & Prognosis - Similar & Future

  • Differential Diagnosis:
    • Anorexia Nervosa (binge-eating/purging type): Distinguished by low body weight.
    • Binge Eating Disorder: Lacks compensatory behaviors.
    • Kleine-Levin Syndrome: Episodic hypersomnia, hyperphagia.
    • MDD (atypical features): Mood symptoms primary; overeating present.
    • GI disorders, CNS tumors: Rule out organic causes for vomiting/bingeing.
  • Prognosis:
    • Course: Often chronic and fluctuating; relapse common (30-50% within 6 months).
    • Good outcome factors: Shorter illness duration, younger onset, good social support.
    • Poor outcome factors: Comorbid personality disorder (esp. borderline), substance abuse, childhood obesity.

⭐ Unlike Anorexia Nervosa, individuals with Bulimia Nervosa are typically of normal weight or overweight, which can delay diagnosis.

High-Yield Points - ⚡ Biggest Takeaways

  • Recurrent binge eating followed by inappropriate compensatory behaviors (e.g., purging, excessive exercise).
  • Diagnosis requires episodes at least once a week for 3 months.
  • Self-esteem is disproportionately linked to body shape and weight.
  • Patients are typically normal weight or overweight, distinguishing from Anorexia Nervosa.
  • Key complications: Russell's sign, dental erosion, parotid hypertrophy, hypokalemia, and metabolic alkalosis.
  • Cognitive Behavioral Therapy (CBT) is the cornerstone of therapy; Fluoxetine (SSRI) is the drug of choice.
  • Often associated with impulsivity, mood disorders, and anxiety disorders.

Practice Questions: Bulimia Nervosa

Test your understanding with these related questions

A young lady presents with a history of repeated episodes of overeating followed by purging using laxatives. She is probably suffering from -

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Flashcards: Bulimia Nervosa

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_____ is the first-line pharmacological treatment for Bulimia nervosa.

TAP TO REVEAL ANSWER

_____ is the first-line pharmacological treatment for Bulimia nervosa.

Fluoxetine

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