Attention-Deficit/Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder

On this page

ADHD Overview - Defining the Buzz

  • Definition: ADHD is a neurodevelopmental disorder characterized by a persistent pattern of inattention and/or hyperactivity-impulsivity that significantly impacts functioning or development across multiple settings.
  • Core Symptom Clusters:
    • Inattention: Difficulty sustaining focus, disorganization.
    • Hyperactivity: Excessive motor activity, restlessness.
    • Impulsivity: Hasty actions, difficulty waiting turns.
  • Epidemiology:
    • Prevalence: Affects ~5-7% of school-aged children globally; Indian data suggests similar rates.
    • Male:Female Ratio: Typically 2:1 to 4:1 in clinical settings.

⭐ Symptoms must be present before age 12 for diagnosis.

ADHD Etiology - Brain's Busy Signals

  • Neurobiology: Core imbalance involves neurotransmitters.
    • Key players: Dopamine (DA) & Norepinephrine (NE) dysregulation.
    • Brain structures implicated:
      • Prefrontal Cortex (executive function).
      • Basal Ganglia (reward, motivation).
      • Cerebellum (timing, coordination).
    • Brain regions implicated in ADHD
  • Genetics: Strong genetic predisposition.
    • High heritability: Estimated at 70-80%.
    • Associated genes: $DRD4$ (dopamine receptor D4), $DAT1$ (dopamine transporter).
    • ⭐ ADHD is one of the most heritable psychiatric disorders.

  • Environmental Risk Factors: Contribute to vulnerability.
    • Prenatal: Maternal smoking, alcohol use during pregnancy.
    • Perinatal: Prematurity, low birth weight (LBW).
    • Postnatal: Exposure to toxins like lead.

ADHD Diagnosis - Spotting the Symptoms

  • Core DSM-5 Criteria:

    • Symptom Duration: ≥6 months.
    • Onset: Several symptoms present before age 12.
    • Impairment: Clinically significant, in ≥2 settings (e.g., home, school/work).

    ⭐ For ADHD diagnosis, symptoms must cause impairment in at least two settings.

  • Symptom Thresholds (DSM-5):

    • Inattention: ≥6/9 symptoms for children (e.g., easily distracted, trouble organizing). For adolescents/adults (age 17+): ≥5/17 symptoms.
    • Hyperactivity/Impulsivity: ≥6/9 symptoms for children (e.g., fidgets, often interrupts). For adolescents/adults (age 17+): ≥5/17 symptoms.
      • 📌 Mnemonic hint: 'CAN I SIT STILL' (hyperactivity/impulsivity).
  • Presentations (Subtypes):

    • Predominantly Inattentive Presentation.
    • Predominantly Hyperactive/Impulsive Presentation.
    • Combined Presentation.
  • Common Comorbidities:

    • Oppositional Defiant Disorder (ODD) (~50%).
    • Conduct Disorder (CD), Anxiety Disorders.
    • Learning Disorders, Mood Disorders, Tic disorders.
  • Differential Diagnosis:

    • Normal active child, situational anxiety.
    • Depression, other mental health conditions.
    • Learning Disorders (LD), Intellectual Disability.
    • Sensory processing issues, Thyroid disorders, sleep disorders.

ADHD Management - Taming the Tornado

  • Core Principle: Multimodal approach (pharmacotherapy + behavioral therapy) is superior for optimal outcomes.

  • Pharmacotherapy:

    • First-line: Stimulants
      • Methylphenidate (MPH): Start 5mg BD/TDS. Max: 60mg/day or 2mg/kg/day.
      • Amphetamines (e.g., Dextroamphetamine).
      • Common Side Effects: Insomnia, ↓appetite, weight loss, headache, abdominal pain, tics.
    • Second-line/Adjuncts: Non-stimulants
      • Atomoxetine (ATX): Start 0.5mg/kg/day, target 1.2mg/kg/day. Max: 100mg/day or 1.4mg/kg/day.
      • Side Effects: GI upset, sedation, ↓appetite, dizziness, ↑HR/BP. ⚠️ Monitor for suicidal ideation (rare).
      • Alpha-2 Agonists: Clonidine, Guanfacine (especially for tics, aggression, sleep issues).
  • Behavioral Interventions:

    • Parent Management Training (PMT): For parents of children <12 years.
    • Behavioral Classroom Management: Teacher-led strategies.
    • Social Skills Training.
    • Cognitive Behavioral Therapy (CBT): For adolescents/adults, addresses co-occurring issues.
  • Monitoring: Regular checks for efficacy, side effects, growth (height, weight), BP, HR.

⭐ Methylphenidate is the most commonly prescribed first-line medication for ADHD.

High‑Yield Points - ⚡ Biggest Takeaways

  • Core features: Persistent inattention, hyperactivity, and impulsivity; symptoms present before age 12.
  • Diagnosis requires impairment in ≥2 settings (e.g., home, school/work).
  • Most prevalent neurodevelopmental disorder of childhood, often persisting.
  • First-line pharmacotherapy: Stimulants (e.g., methylphenidate, amphetamines) are most effective.
  • Alternative medications: Non-stimulants like atomoxetine, guanfacine, or clonidine.
  • Frequently associated with comorbidities: ODD, conduct disorder, anxiety, and learning disabilities.
  • Symptoms may persist into adulthood, though hyperactivity often lessens an_d inattention may predominate_

Practice Questions: Attention-Deficit/Hyperactivity Disorder

Test your understanding with these related questions

Which of the following drugs are used in the treatment of Attention-Deficit Hyperactivity Disorder (ADHD)?

1 of 5

Flashcards: Attention-Deficit/Hyperactivity Disorder

1/10

Memory and thinking deficits and specific learning disabilities maybe seen in _____

TAP TO REVEAL ANSWER

Memory and thinking deficits and specific learning disabilities maybe seen in _____

ADHD

browseSpaceflip

Enjoying this lesson?

Get full access to all lessons, practice questions, and more.

Start Your Free Trial