Panic Disorder

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Panic Disorder: Definition & Epidemiology - Panic Stats Attack

  • Definition: Panic Disorder involves recurrent, unexpected panic attacks. A panic attack is an abrupt surge of intense fear or overwhelming discomfort that peaks within minutes. Absence of a specific trigger is key for "unexpected".
  • Core Epidemiology:

⭐ Panic disorder has a lifetime prevalence of approximately 2-5%. It is 2-3 times more common in females than males, with onset typically occurring in late adolescence or early adulthood (e.g., 20-24 years).

Panic Disorder: Clinical Features - Fear Eruption Now

Panic Attack: Abrupt surge of intense fear/discomfort, peaks in minutes. Requires ≥4 of 13 symptoms:

  • Palpitations/↑HR
  • Sweating
  • Trembling
  • SOB/smothering
  • Choking
  • Chest pain
  • Nausea/GI distress
  • Dizziness/faintness
  • Chills/hot flushes
  • Paresthesias
  • Derealization/Depersonalization
  • Fear losing control/"crazy"
  • Fear dying

📌 Mnemonic: FEAR PANICS (Fear of dying/losing control, Excessive heart rate, Aching chest, Respiratory distress, Paresthesias, Abdominal distress, Nausea, Intense depersonalization/derealization, Chills/hot flushes, Sweating/shaking).

Man experiencing panic attack symptoms

Panic Disorder (DSM-5):

  • Recurrent unexpected panic attacks.
  • ≥1 month of either:
    • Persistent worry: more attacks/consequences.
    • Maladaptive behavior change due to attacks.
  • Not due to substances, medical conditions, or other mental disorders.
  • Often co-occurs with agoraphobia.

⭐ Key: Recurrent unexpected attacks + ≥1 month persistent concern/worry about more attacks or their consequences.

Panic Disorder: Etiology & DDx - Mind's Mayday Call

  • Etiology
    • Neurobiological Factors:
      • Noradrenergic: ↑ locus coeruleus activity (fear network).
      • Serotonergic: Dysregulation impacts anxiety.
      • GABAergic: ↓ inhibition (benzodiazepine receptor involvement).
      • $CO_2$ Hypersensitivity: "Suffocation false alarm"; chemoreceptors overreact to $CO_2$.
    • Genetic Predisposition: Significant heritability; ↑ risk in first-degree relatives.
    • Cognitive Theories:
      • Learning: Neutral cues become conditioned triggers.
      • Catastrophic Misinterpretation: Bodily sensations (palpitations) seen as imminent threat.

Panic Attack Model

⭐ The 'suffocation false alarm' theory highlights a hypersensitivity to internal bodily cues, often linked to carbon dioxide levels, precipitating panic.

  • Differential Diagnoses (DDx)

    CategoryKey Examples
    CardiacMyocardial Infarction (MI), Arrhythmias
    RespiratoryAsthma, Pulmonary Embolism (PE)
    EndocrineHyperthyroidism, Pheochromocytoma, Hypoglycemia
    NeurologicalSeizures, Transient Ischemic Attack (TIA)
    Other PsychiatricGAD, Social Anxiety Disorder, PTSD, Illness Anxiety Disorder, Substance Withdrawal
    Drug-InducedStimulants (caffeine, amphetamines), Akathisia

Panic Disorder: Management - Panic Taming Plan

  • Pharmacotherapy:
    • SSRIs (e.g., Fluoxetine, Sertraline, Paroxetine): First-line. Start low, go slow.
    • SNRIs (e.g., Venlafaxine): Alternative first-line.
    • Benzodiazepines (e.g., Clonazepam, Alprazolam): Acute, short-term relief for severe symptoms; taper to avoid withdrawal. High dependence risk.
    • TCAs (e.g., Imipramine), MAOIs: For treatment-resistant cases; more side effects.
  • Psychotherapy:
    • Cognitive Behavioral Therapy (CBT): First-line, highly effective. Includes:
      • Psychoeducation about panic.
      • Cognitive restructuring (challenging catastrophic thoughts & misinterpretations of bodily sensations).
      • Interoceptive exposure (gradual exposure to feared physical sensations).
      • In vivo exposure (gradual exposure to feared situations).
  • Combined Approach: SSRIs + CBT often most effective, especially for severe cases.
  • Continue effective treatment for ~12-24 months after remission to prevent relapse.

SSRIs (e.g., fluoxetine, sertraline, paroxetine) are the first-line pharmacological treatment for Panic Disorder due to their efficacy and favorable side-effect profile compared to older agents.

High‑Yield Points - ⚡ Biggest Takeaways

  • Recurrent unexpected panic attacks are the hallmark.
  • Attacks involve intense fear, peaking within 10 minutes.
  • Followed by ≥1 month of persistent concern about future attacks or maladaptive behavior changes.
  • Agoraphobia is a frequent comorbidity, not a diagnostic necessity.
  • First-line treatments are SSRIs (e.g., fluoxetine) and CBT.
  • Benzodiazepines (e.g., alprazolam) for acute management or short-term.
  • Always exclude medical conditions (cardiac, thyroid) and substance use.

Practice Questions: Panic Disorder

Test your understanding with these related questions

A 24-year-old lady presented with sudden onset chest pain, palpitations lasting for about 20 minutes. She says there were 3 similar episodes in the past. All the investigations were normal. What is the likely diagnosis?

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Flashcards: Panic Disorder

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First-line treatment for social anxiety disorder includes _____ + SSRIs or venlafaxine

TAP TO REVEAL ANSWER

First-line treatment for social anxiety disorder includes _____ + SSRIs or venlafaxine

CBT

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