Agoraphobia

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Introduction & Epidemiology - Crowd Fear Defined

  • Definition: Marked fear/anxiety about ≥2 agoraphobic situations (e.g., public transport, open/enclosed spaces, crowds, outside home alone).
  • Core Fear: Escape difficult or help unavailable if panic-like/incapacitating symptoms occur.
  • Epidemiology:
    • Prevalence: ~1.7% (12-month).
    • Age of Onset: Late adolescence/early adulthood (mean ~20 yrs).
    • Gender: Females > Males (F:M ≈ 2:1).

⭐ Agoraphobia often develops as a complication of panic disorder.

Clinical Features & DSM-5 - Panic's Prison Walls

  • Key Agoraphobic Situations (📌 Mnemonic: PLACES): Marked fear/anxiety about ≥2 of:
    • Public transport
    • Lines/Crowds
    • Away from home (being alone)
    • Closed spaces (e.g., shops, theatres)
    • Empty/Open spaces (e.g., parking lots, markets)
  • Central Cognitive Theme: Thoughts that escape difficult/help unavailable if panic-like or other incapacitating/embarrassing symptoms (e.g., fear of falling, incontinence) occur.
  • DSM-5 Essentials:
    • Situations actively avoided, require a companion, or endured with intense fear/anxiety.
    • Symptoms persist for ≥6 months.
    • Causes clinically significant distress or impairment (social, occupational).
    • The fear/anxiety is out of proportion to the actual danger posed by the agoraphobic situations and to the sociocultural context. Agoraphobia Symptoms

Differential Diagnosis & Comorbidity - What Else Lurks?

Key Differential Diagnoses:

ConditionDifferentiating Feature (vs. Agoraphobia)
Panic DisorderFear of panic attack itself, not just difficult escape
Social AnxietyFear of social scrutiny/negative evaluation
Specific PhobiaFear limited to one specific object/situation
PTSDAnxiety from re-experiencing trauma
MDD + PsychosisAvoidance due to delusions, not primary anxiety
Medical ConditionsSymptoms due to direct physiological effects (e.g., thyrotoxicosis)
  • Other anxiety disorders (Panic Disorder, GAD)
  • Depression (MDD)
  • Substance Use Disorders (SUD)

⭐ Approximately 50% of individuals with agoraphobia also have a current panic disorder.

Management - Escape Route Plan

Exposure therapy is the most effective psychological treatment for agoraphobia.

  • Core Approach: Combination of psychotherapy & pharmacotherapy often optimal.
  • Psychotherapy (1st Line):
    • Cognitive Behavioral Therapy (CBT): Gold standard.
      • Exposure Therapy: Key component.
        • Principles: Gradual, systematic, prolonged, repeated confrontation with feared situations/sensations (in vivo > imaginal).
        • Develop an "exposure hierarchy".
        • Goal: Habituation, reduce avoidance.
  • Pharmacotherapy:
    • First-line:
      • SSRIs: Sertraline (50-200 mg/day), Paroxetine (20-60 mg/day). Start low, titrate slowly.
      • SNRIs: Venlafaxine XR (75-225 mg/day).
    • Second-line / Adjunctive:
      • TCAs: (e.g., Imipramine) if SSRI/SNRI ineffective/contraindicated.
      • Benzodiazepines (BZDs): (e.g., Clonazepam 0.5-2 mg PRN) for short-term relief of severe anxiety; ⚠️ high dependence risk, avoid long-term monotherapy.

Graded exposure therapy steps for agoraphobia

Prognosis & Course - Freedom's Forecast

  • Course: Often chronic if untreated; symptoms wax & wane.
  • Better Prognosis:
    • Early treatment.
    • No comorbid personality disorder.
    • Good social support.
    • Later age of onset.
  • Worse Prognosis:
    • Comorbid depression/anxiety.
    • Severe panic symptoms & avoidance.
    • Early age of onset.
  • Remission: ~50-60% with therapy (CBT) & SSRIs.
  • QoL Impact: Severe if untreated; affects daily, social, work life.

⭐ Early treatment is associated with a better prognosis in agoraphobia.

High‑Yield Points - ⚡ Biggest Takeaways

  • Agoraphobia: Marked fear/anxiety about ≥2 situations (e.g., public transport, open/enclosed spaces, crowds, outside home alone).
  • Core fear: difficult escape or unavailable help if panic-like or incapacitating symptoms arise.
  • Situations are actively avoided, require a companion, or are endured with intense fear.
  • The fear/anxiety is out of proportion to the actual danger posed by the situations.
  • Symptoms persist for ≥6 months and cause clinically significant distress or impairment.
  • Treatment: SSRIs are first-line pharmacotherapy; Cognitive Behavioral Therapy (CBT), especially exposure therapy, is key psychotherapy.
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Practice Questions: Agoraphobia

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A middle-aged person reported to the Psychiatric OPD with complaints of fear of leaving home, fear of traveling alone, and fear of being in a crowd. He develops marked anxiety with palpitations and sweating when he is in these situations. He often avoids public transportation to go to his place of work. The most likely diagnosis is

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Flashcards: Agoraphobia

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First-line treatment for social anxiety disorder includes _____ + SSRIs or venlafaxine

TAP TO REVEAL ANSWER

First-line treatment for social anxiety disorder includes _____ + SSRIs or venlafaxine

CBT

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