Anxiety Disorders

Anxiety Disorders Indian Medical PG Question 1: A 19-year-old man working as a driver comes to Psychiatrist with excessive anxiety and fear. He reports that every time he drives over a bump in the road, he is convinced that he has accidentally run over a small child. He has to pull over and check underneath his car for blood and retrace his driving route to look for any injured children. As a result, he is always late for work. He also has intrusive thoughts about stabbing his coworkers. He prays to try to erase these thoughts from his mind, but this rarely helps. First-line pharmacological treatment of this patient's condition primarily affects which of the following neurotransmitters?

• A. Dopamine
• B. Serotonin (Correct Answer)
• C. Norepinephrine
• D. Acetylcholine

Anxiety Disorders Explanation: ***Serotonin*** - The described symptoms (obsessive thoughts about harming others, compulsive checking, and attempts to neutralize thoughts with prayer) are highly characteristic of **Obsessive-Compulsive Disorder (OCD)**. - **Selective Serotonin Reuptake Inhibitors (SSRIs)** are the first-line pharmacological treatment for OCD, and they work by increasing the availability of serotonin in the synaptic cleft. *Dopamine* - Dopamine dysregulation is primarily implicated in disorders such as **schizophrenia** and **Parkinson's disease**, and to some extent in ADHD and addiction. - While dopamine may play a role in some aspects of OCD, typical first-line treatments do not primarily target dopamine. *Norepinephrine* - Norepinephrine is largely involved in the **fight-or-flight response**, attention, and arousal, and is a target for treating depression and anxiety disorders with SNRIs. - While some antidepressants that affect norepinephrine may be used if SSRIs are ineffective, they are not considered the primary neurotransmitter target for first-line OCD treatment. *Acetylcholine* - Acetylcholine is crucial for **muscle contraction**, learning, and memory, and imbalances are associated with conditions like **Alzheimer's disease** and myasthenia gravis. - It is not a primary target for the pharmacological treatment of OCD.

Anxiety Disorders Indian Medical PG Question 2: Which of the following disorders is classified under somatic symptom and related disorders in the DSM-5?

• A. Post-Traumatic Stress Disorder (PTSD)
• B. Phobic disorders (e.g., social anxiety disorder)
• C. Conversion disorder (functional neurological symptom disorder) (Correct Answer)
• D. Obsessive-Compulsive Disorder (OCD)

Anxiety Disorders Explanation: ***Conversion disorder (functional neurological symptom disorder)*** - **Conversion disorder** is characterized by neurological symptoms (e.g., paralysis, blindness) that are **incompatible with recognized neurological or medical conditions**, yet are not intentionally produced. - It falls under **somatic symptom and related disorders** because the primary features are physical symptoms causing distress or functional impairment, rather than being malingered or feigned. *Phobic disorders (e.g., social anxiety disorder)* - **Phobic disorders** are classified under **anxiety disorders** in the DSM-5, not somatic symptom and related disorders. - They are primarily characterized by **intense, irrational fears** of specific objects or situations, leading to avoidance rather than prominent physical symptoms without a medical cause. *Post-Traumatic Stress Disorder (PTSD)* - **PTSD** is classified under **trauma- and stressor-related disorders** in the DSM-5, distinguished by symptoms developing after exposure to a traumatic event. - Its core features include **intrusive memories, avoidance, negative alterations in cognition and mood, and alterations in arousal and reactivity**, rather than unexplained physical symptoms. *Obsessive-Compulsive Disorder (OCD)* - **OCD** is classified under **obsessive-compulsive and related disorders** in the DSM-5. - It is primarily characterized by the presence of **obsessions (recurrent, intrusive thoughts)** and/or **compulsions (repetitive behaviors or mental acts)**, which are distinct from somatic symptoms.

Anxiety Disorders Indian Medical PG Question 3: What is the treatment of choice for acute panic attacks?

• A. Tricyclic antidepressants (TCAs)
• B. Monoamine oxidase inhibitors (MAOIs)
• C. Barbiturates
• D. Benzodiazepines (Correct Answer)

Anxiety Disorders Explanation: ***Correct: Benzodiazepines*** - Benzodiazepines are the **treatment of choice for acute panic attacks** due to their **rapid onset of action** (within minutes) - They work by enhancing **GABA-A receptor** activity, providing immediate anxiolytic effects - Commonly used agents include **alprazolam, lorazepam, and clonazepam** - While effective acutely, they are not recommended for long-term management due to dependence risk *Incorrect: Tricyclic antidepressants (TCAs)* - TCAs are effective for **long-term prophylaxis** of panic disorder, not acute attacks - They have a **delayed onset of action** (2-4 weeks), making them unsuitable for immediate relief - Significant **anticholinergic effects** and potential cardiotoxicity limit their use *Incorrect: Monoamine oxidase inhibitors (MAOIs)* - MAOIs can be effective for panic disorder but are reserved for **treatment-resistant cases** - **Delayed onset of action** (several weeks) makes them inappropriate for acute attacks - Require **dietary restrictions** and have risk of hypertensive crisis with tyramine-containing foods *Incorrect: Barbiturates* - Largely **obsolete** in psychiatric practice, replaced by safer benzodiazepines - **Narrow therapeutic index** with high risk of overdose and respiratory depression - Greater potential for dependence and withdrawal complications - No role in modern management of panic attacks

Anxiety Disorders Indian Medical PG Question 4: A patient with a history of RTA before 2 months presents with complaints of dreams of accidents. He is able to visualize the same scene whenever he visits the place. Hence is afraid to go back to the accident site. Identify the type of disorder that he might be suffering from?

• A. PTSD (Correct Answer)
• B. Anxiety disorder
• C. Obsessive-Compulsive Disorder (OCD)
• D. Adjustment disorder

Anxiety Disorders Explanation: ***PTSD*** - The patient's symptoms, including **recurrent dreams** of the accident, **intrusive memories** triggered by the accident site, and **avoidance** of the location, are classic diagnostic criteria for **Post-Traumatic Stress Disorder (PTSD)**. - PTSD often develops after exposure to a **traumatic event** like a car accident, with symptoms lasting for more than one month. *Anxiety disorder* - While anxiety is a prominent feature of PTSD, **Generalized Anxiety Disorder** typically involves excessive worry about everyday events rather than a specific traumatic incident. - Other anxiety disorders like **panic disorder** involve sudden, intense fear without the specific re-experiencing and avoidance symptoms seen here. *Obsessive-Compulsive Disorder (OCD)* - OCD is characterized by repetitive, unwanted thoughts (**obsessions**) and ritualistic behaviors (**compulsions**) performed to reduce anxiety, which are not described in this patient's presentation. - The patient's distress stems from a past trauma, not from obsessions or compulsions. *Adjustment disorder* - An adjustment disorder occurs in response to a **stressor**, but the symptoms are typically less severe and do not include the full constellation of **re-experiencing, avoidance, and hyperarousal** seen in PTSD. - An adjustment disorder resolves within 6 months of the stressor or its consequences, however, the persistence and nature of the symptoms here point to a more severe trauma-related condition.

Anxiety Disorders Indian Medical PG Question 5: Which of the following is the most prevalent psychiatric disorder in the general population?

• A. Schizophrenia
• B. Mania
• C. Anxiety disorder (Correct Answer)
• D. Depression

Anxiety Disorders Explanation: ***Anxiety disorder*** - **Anxiety disorders** are collectively the most prevalent psychiatric disorders in the general population, affecting approximately **10-30% of individuals** during their lifetime. - This category includes **specific phobias, social anxiety disorder, panic disorder, generalized anxiety disorder, and others**, which together have the highest prevalence among all psychiatric conditions. - Epidemiological studies consistently show that **anxiety disorders surpass depression** in terms of overall prevalence in community samples. *Depression* - **Major depressive disorder** is highly prevalent (lifetime prevalence approximately 10-15%) and is the **leading cause of disability worldwide**. - While extremely common and clinically significant, it is slightly less prevalent than anxiety disorders when considering community-based epidemiological data. - Depression often occurs **co-morbidly with anxiety disorders**, further emphasizing the importance of both conditions. *Schizophrenia* - **Schizophrenia** is a severe chronic mental illness with a much lower prevalence, affecting approximately **0.3-0.7%** of the general population. - Despite its significant impact on affected individuals and families, its overall prevalence is relatively low compared to mood and anxiety disorders. *Mania* - **Mania** is a mood state characteristic of **bipolar disorder**, which has a prevalence of approximately **1-2%** of the population. - This is considerably lower than the prevalence of both anxiety disorders and major depressive disorder.

Anxiety Disorders Indian Medical PG Question 6: Which of the following is NOT a characteristic feature of delirium tremens?

• A. Severe depression (Correct Answer)
• B. Extreme anxiety
• C. Delusion
• D. Hallucination

Anxiety Disorders Explanation: ***Severe depression*** - While mood disturbances can occur with alcohol withdrawal, **severe depression** is not a hallmark or defining feature of **delirium tremens (DTs)** itself. - DTs primarily manifest as severe autonomic hyperactivity, altered mental status, and perceptual disturbances. *Hallucination* - **Hallucinations**, particularly **visual** (e.g., seeing insects or small animals), are a classic and common feature of delirium tremens. - These perceptual disturbances contribute significantly to the agitated and disoriented state of patients experiencing DTs. *Extreme anxiety* - **Extreme anxiety**, agitation, and fear are very common in delirium tremens due to the heightened state of arousal and terrifying hallucinations. - This **hyperarousal** is a direct result of the severe autonomic dysregulation. *Delusion* - **Delusions**, often **paranoid** or referring to being persecuted, are frequently observed in patients with delirium tremens. - These fixed, false beliefs contribute to the patient's confusion, fear, and sometimes aggressive behavior.

Anxiety Disorders Indian Medical PG Question 7: What is the first-line treatment for generalized anxiety disorder?

• A. SSRIs (Correct Answer)
• B. Antipsychotics
• C. Benzodiazepines
• D. MAO inhibitors

Anxiety Disorders Explanation: ***SSRIs*** - **Selective Serotonin Reuptake Inhibitors (SSRIs)** are considered first-line pharmacological treatment for generalized anxiety disorder due to their efficacy and generally favorable side effect profile. - They work by increasing the levels of **serotonin** in the brain, which helps regulate mood and anxiety symptoms. *Antipsychotics* - **Antipsychotics** are primarily used to treat psychotic disorders like schizophrenia or severe mood disorders with psychotic features, not typically as first-line for generalized anxiety disorder. - Their significant side effect profile, including metabolic disturbances and movement disorders, makes them a less desirable choice for initial treatment of anxiety. *Benzodiazepines* - While effective for acute anxiety relief, **benzodiazepines** are generally not considered first-line for long-term management of GAD due to the risk of dependence, tolerance, and withdrawal symptoms. - They are often used for short-term relief or as an adjunct in the initial phase of treatment while awaiting the therapeutic effects of SSRIs. *MAO inhibitors* - **Monoamine Oxidase Inhibitors (MAOIs)** are older antidepressants with significant drug-drug and drug-food interactions (e.g., tyramine crisis), making them usually a last-resort treatment for severe mood disorders, not generalized anxiety disorder. - Their complex dietary restrictions and side effect profile preclude their use as a first-line option.

Anxiety Disorders Indian Medical PG Question 8: A 45-year-old female presents to the OPD with complaints of "feeling tense" and experiencing stomach upset with heartburn and diarrhea. She reports having these symptoms for many years and mentions that her family members also usually feel tense and nervous. Which of the following symptoms is most likely to be seen in this patient?

• A. Ideas of reference
• B. Tingling of extremities (Correct Answer)
• C. Hallucination
• D. Neologism

Anxiety Disorders Explanation: ***Tingling of extremities*** - The patient's presentation of "feeling tense," **stomach upset, heartburn, and diarrhea** for many years, alongside a family history of similar issues, suggests significant **anxiety**. - **Peripheral neurological symptoms** such as **tingling of extremities (paresthesia)** are common manifestations of anxiety and panic attacks due to **hyperventilation** (causing respiratory alkalosis and decreased ionized calcium) and **physiological arousal**. *Ideas of reference* - **Ideas of reference** are typically seen in **psychotic disorders** (e.g., schizophrenia) where a person believes that unrelated, external events have a special, personal meaning. - While anxiety can sometimes lead to misinterpretations, **ideas of reference** at a delusional level are not characteristic of generalized anxiety. *Hallucination* - **Hallucinations** are perceptual disturbances where an individual experiences sensory perceptions (e.g., hearing voices, seeing things) in the absence of an external stimulus. - These are core symptoms of **psychotic disorders** and are not typical findings in anxiety disorders without comorbid conditions. *Neologism* - A **neologism** is the coining of new words or phrases, often without clear meaning, which is a hallmark feature of disorganized thought in **psychotic disorders** (e.g., schizophrenia). - This symptom is related to severe thought disorganization and is not associated with anxiety disorders.

Anxiety Disorders Indian Medical PG Question 9: Which of the following speech patterns is most indicative of Wernicke's aphasia?

• A. Normal speech with comprehension
• B. Non-fluent speech with intact comprehension
• C. Fluent but nonsensical speech (Correct Answer)
• D. Speech with meaningful content

Anxiety Disorders Explanation: ***Fluent but nonsensical speech*** - Wernicke's aphasia is characterized by **fluent**, often grammatically correct, speech that is **devoid of meaning** and often includes **paraphasias** (word substitutions) and **neologisms** (made-up words). - Patients have significant **comprehension deficits**, making meaningful conversation difficult despite preserved speech fluency. - This is also known as **receptive aphasia** or **sensory aphasia**, caused by damage to Wernicke's area in the superior temporal gyrus. *Normal speech with comprehension* - This describes **healthy speech patterns**, where both production and understanding of language are intact. - It directly contradicts the definition of **aphasia**, which involves impairment in language abilities. *Non-fluent speech with intact comprehension* - This describes **Broca's aphasia** (expressive aphasia), where speech production is effortful and halting. - Unlike Wernicke's aphasia, patients with Broca's aphasia have **preserved comprehension** but struggle with speech output. - The key differentiator is that Wernicke's has **fluent speech with poor comprehension**, while Broca's has **non-fluent speech with good comprehension**. *Speech with meaningful content* - This indicates that the speaker can convey understandable and relevant information, which is precisely what is lacking in **Wernicke's aphasia**. - In Wernicke's aphasia, the content is typically **empty** or **circumlocutory**, making it difficult to extract any coherent meaning.

Anxiety Disorders Indian Medical PG Question 10: Along with a pleasant stimulus, noxious stimuli are given in the treatment of alcohol dependence or sexual disorder. This is which of the following types of behavior therapy?

• A. Negative reinforcement
• B. Aversion therapy (Correct Answer)
• C. Punishment
• D. Flooding

Anxiety Disorders Explanation: ### Explanation **Correct Answer: B. Aversion Therapy** **Aversion therapy** is a form of behavior therapy based on the principle of **Classical Conditioning**. It involves the repeated pairing of an undesirable but pleasant stimulus (e.g., alcohol or paraphilic triggers) with an unpleasant/noxious stimulus (e.g., electric shocks, emetics like disulfiram, or unpleasant odors). Over time, the patient develops a conditioned aversion to the previously pleasurable stimulus, leading to a reduction in the unwanted behavior. It is commonly used in treating alcohol dependence, smoking, and certain sexual disorders. **Why other options are incorrect:** * **A. Negative Reinforcement:** This involves the **removal** of an unpleasant stimulus to increase the frequency of a desired behavior (e.g., taking an aspirin to remove a headache). In the question, a noxious stimulus is *added*, not removed. * **C. Punishment:** While similar, punishment is an **Operant Conditioning** concept where a consequence follows a behavior to decrease its frequency. Aversion therapy is specifically the *pairing* of stimuli to change the emotional response (Classical Conditioning). * **D. Flooding:** This is a technique used for phobias and OCD where the patient is directly exposed to their maximum feared stimulus (prolonged exposure) until the anxiety response extinguishes. It does not involve noxious stimuli like shocks or chemicals. **High-Yield Clinical Pearls for NEET-PG:** * **Disulfiram (Antabuse):** A classic example of aversion therapy (pharmacological) used in alcohol dependence by causing a toxic reaction (DER). * **Covert Sensitization:** A variation of aversion therapy where the noxious stimulus is merely **imagined** rather than physically applied. * **Systematic Desensitization:** The opposite of flooding; it involves graded exposure combined with relaxation techniques (based on reciprocal inhibition).

Anxiety Disorders Flashcard 1 of 10

Question: What neurotransmitters are decreased in anxiety? _____ and GABA

Answer: Serotonin

Anxiety Disorders Flashcard 2 of 10

Question: Anxiety disorders are associated with _____ insomnia

Answer: sleep onset

Anxiety Disorders Flashcard 3 of 10

Question: _____ disorder is defined as anxiety unrelated to a specific person, situation, or event for > 6 months (duration)

Answer: Generalized anxiety

Anxiety Disorders Flashcard 4 of 10

Question: _____ (depression or anxiety) is characterized by increased norepinephrine

Answer: Anxiety

Anxiety Disorders Flashcard 5 of 10

Question: Panic attacks may be treated acutely with _____ or propranolol

Answer: benzodiazepines

Anxiety Disorders Flashcard 6 of 10

Question: First-line treatment for panic disorder includes _____ + SSRIs or venlafaxine

Answer: CBT

Anxiety Disorders Flashcard 7 of 10

Question: _____ (depression or anxiety) is characterized by decreased GABA

Answer: Anxiety

Anxiety Disorders Flashcard 8 of 10

Question: First-line treatment for social anxiety disorder includes _____ + SSRIs or venlafaxine

Answer: CBT

Anxiety Disorders Flashcard 9 of 10

Question: Diagnosis of _____ disorder requires at least one panic attack, followed by at least one month (duration) of preoccupations with the attack

Answer: panic

Anxiety Disorders Flashcard 10 of 10

Question: _____ is defined as severe, persistent fear or anxiety triggered by specific things, situations, or environments for > 6 months (duration)

Answer: Specific phobia