Somatosensation

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Receptors & Modalities - Touchy Feely Bits

Somatosensation: touch, pressure, vibration, pain, temperature. Specialized receptors detect these.

  • Receptor Types & Properties:
    • Mechanoreceptors: Detect mechanical stimuli.
      • Encapsulated: Meissner's, Pacinian, Ruffini's.
      • Unencapsulated: Merkel's, Free nerve endings (FNE).
    • Adaptation: 📌 "MaP out Rapid changes (Meissner, Pacinian = Rapidly Adapting)."
      • Rapidly Adapting (RA/Phasic): Signal changes (e.g., Meissner's, Pacinian).
      • Slowly Adapting (SA/Tonic): Signal intensity/duration (e.g., Merkel's, Ruffini's).
ReceptorAdapSensation(s)Location
Meissner'sRALight touch, Low-vibGlabrous (sup)
PacinianRAHigh-vib, Deep pressureDeep dermis
Merkel'sSATouch, Pressure, FormEpidermis
Ruffini'sSAStretch, Sust. pressureDermis, joints
FNEVarPain, Temp, ItchWidespread

⭐ A-delta (Aδ) fibers (myelinated) transmit fast, sharp, localized pain; C fibers (unmyelinated) transmit slow, dull, diffuse pain.

Ascending Pathways - Info Superhighways

  • Dorsal Column-Medial Lemniscus (DCML) Pathway:
    • Senses: Fine touch, vibration, proprioception.
    • Fibers: Aβ (fast). Decussates: Medulla.
  • Anterolateral System (ALS) / Spinothalamic Tract:
    • Senses: Pain, temperature, crude touch.
    • Fibers: Aδ & C (slower). Decussates: Spinal cord.

Spinal cord cross-section with sensory tracts

⭐ Syringomyelia, a central cord syndrome, classically damages crossing fibers in the anterior white commissure, causing bilateral loss of pain & temperature at affected levels (cape-like distribution).

Cortical Processing - Brain's Touch Map

  • Primary Somatosensory Cortex (S1):
    • Brodmann areas 3, 1, 2 (postcentral gyrus).
    • Receives thalamic input (VPL/VPM nuclei).
  • Sensory Homunculus (Somatotopy):
    • Distorted cortical map; area reflects receptor density.
    • Large representation: Lips, hands, face.
    • Small representation: Trunk, legs. Sensory Homunculus Diagram
  • Columnar Organization:
    • Vertical columns in S1; each responds to specific modality & location.
  • Secondary Somatosensory Cortex (S2):
    • Location: Superior bank, lateral sulcus.
    • Input from S1; role in tactile learning & memory.
  • Posterior Parietal Cortex (Areas 5, 7):
    • Integrates somatosensory with other senses (e.g., visual).
    • Spatial orientation, body image, attention.

    ⭐ Lesions in posterior parietal cortex (Areas 5, 7) can cause contralateral neglect syndrome or astereognosis (tactile agnosia).

  • Cortical Plasticity: Maps can reorganize after injury or with experience (e.g., phantom limb).

Pain & Temperature - Ouch & Hot Spots

  • Nociceptors (Pain): Free nerve endings.
    • Aδ fibers: Myelinated; fast, sharp, localized pain (Glutamate).
    • C fibers: Unmyelinated; slow, dull, burning, diffuse pain (Substance P, CGRP).
  • Thermoreceptors: Free nerve endings.
    • Cold (Aδ, C): Peak 20-35°C. Paradoxical cold >45°C.
    • Warm (C): Peak 30-45°C. Pain >45°C.
  • Pathway: Anterolateral System (Spinothalamic Tract).
  • Gate Control: Aβ (touch) fibers activate inhibitory interneurons (SG), reducing Aδ/C pain transmission.
  • Pain Modulation:
    • Endogenous opioids: Enkephalins, endorphins.
    • Descending inhibition: PAG → Raphe (5-HT), Locus Coeruleus (NE) → Dorsal Horn.
  • 📌 Mnemonic: Aδ = Alert (fast), C = Chronic (slow). Gate Control Theory of Pain Diagram

Allodynia: Pain from non-painful stimuli (e.g., light touch). Common in neuropathic pain.

High‑Yield Points - ⚡ Biggest Takeaways

  • DCML pathway carries fine touch, vibration, proprioception; decussates in medulla.
  • Anterolateral system transmits pain, temperature, crude touch; decussates in spinal cord.
  • Key mechanoreceptors: Meissner's (light touch), Pacinian (vibration), Merkel's (pressure), Ruffini's (stretch).
  • Brown-Séquard syndrome: ipsilateral DCML loss, contralateral ALS loss below lesion.
  • Thalamic relay: VPL nucleus for body, VPM nucleus for face.
  • Dermatomes (e.g., T4 nipple, T10 umbilicus, L4 knee) aid lesion localization.
  • Gate control theory modulates pain at spinal cord; basis for TENS therapy.

Practice Questions: Somatosensation

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Ablation of the somatosensory area I of the cerebral cortex leads to

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Flashcards: Somatosensation

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Which types of sensory receptor adapt quickly? _____ and Meissner corpuscles

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Which types of sensory receptor adapt quickly? _____ and Meissner corpuscles

Pacinian corpuscles

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