Anaphylaxis Indian Medical PG Practice Questions and MCQs
Practice Indian Medical PG questions for Anaphylaxis. These multiple choice questions (MCQs) cover important concepts and help you prepare for your exams.
Anaphylaxis Indian Medical PG Question 1: A cardiovascular parameter helpful in diagnosis of anaphylaxis during anaesthesia:
- A. Bradycardia
- B. Dysrhythmia
- C. Increased peripheral vascular resistance
- D. Hypotension (Correct Answer)
Anaphylaxis Explanation: ***Hypotension***
- **Hypotension** is a hallmark cardiovascular sign of anaphylaxis, occurring due to widespread **vasodilation** and increased vascular permeability.
- This symptom is often profound and unresponsive to initial fluid resuscitation due to the ongoing systemic release of inflammatory mediators.
*Bradycardia*
- While bradycardia can occur in some rare cases of anaphylaxis (e.g., **vasovagal response**), **tachycardia** is the more common cardiac response due to compensatory mechanisms.
- It is not a primary or consistent indicator of anaphylaxis, making it less helpful for diagnosis in this context.
*Dysrhythmia*
- **Dysrhythmias** can occur during anaphylaxis due to myocardial ischemia or electrolyte imbalances, but they are not a direct or consistent diagnostic feature.
- Their presence often reflects severe compromise or co-existing conditions rather than being a primary anaphylactic sign.
*Increased peripheral vascular resistance*
- Anaphylaxis is characterized by a significant **decrease in peripheral vascular resistance** due to mast cell and basophil degranulation releasing vasodilatory mediators like histamine.
- Therefore, an increase in peripheral vascular resistance would contradict the pathophysiology of anaphylaxis.
Anaphylaxis Indian Medical PG Question 2: A man takes peanut and develops tongue swelling, neck swelling, stridor, hoarseness of voice. What is the probable diagnosis?
- A. FB in larynx
- B. Angioneurotic edema (Correct Answer)
- C. Parapharyngeal abscess
- D. FB bronchus
Anaphylaxis Explanation: Andioneurotic edema
- The combination of **tongue swelling**, **neck swelling**, **stridor**, and **hoarseness of voice** following peanut ingestion is highly suggestive of **angioneurotic edema**, a severe allergic reaction that can lead to airway obstruction [1].
- This is a life-threatening condition requiring immediate medical intervention, often associated with generalized **anaphylaxis** when triggered by allergens [2].
*FB in larynx*
- While a **foreign body (FB) in the larynx** can cause stridor and hoarseness, the widespread swelling of the tongue and neck points away from a localized laryngeal obstruction [3].
- A laryngeal FB would typically be associated with a more sudden onset of choking and coughing, not diffuse edema [3].
*Parapharyngeal abscess*
- A **parapharyngeal abscess** would typically present with **fever**, **severe throat pain**, and **trismus** (difficulty opening the mouth), which are not mentioned in this scenario.
- The acute, rapid onset of symptoms after peanut consumption is inconsistent with the slower progression of an abscess.
*FB bronchus*
- A **foreign body in the bronchus** would primarily cause **coughing**, **wheezing**, and possibly **respiratory distress**, often unilateral, rather than severe global swelling of the tongue and neck.
- Inspiratory stridor and hoarseness are more indicative of upper airway involvement than bronchial obstruction.
Anaphylaxis Indian Medical PG Question 3: A child with a known peanut allergy accidentally ingests a food containing peanuts and develops urticaria, vomiting, and wheezing within minutes. What is the first-line treatment?
- A. Oral antihistamines
- B. Subcutaneous epinephrine
- C. Intramuscular epinephrine (Correct Answer)
- D. High-dose corticosteroids
Anaphylaxis Explanation: ***Intramuscular epinephrine***
- This patient is experiencing **anaphylaxis**, characterized by rapid-onset **urticaria**, **vomiting** (gastrointestinal involvement), and **wheezing** (respiratory involvement).
- **Epinephrine** is the **first-line treatment** for anaphylaxis due to its alpha-1 agonist effects (vasoconstriction to counteract hypotension and reduce angioedema) and beta-2 agonist effects (bronchodilation to relieve wheezing). Intramuscular administration ensures rapid absorption and systemic effect.
*Oral antihistamines*
- While antihistamines can help manage cutaneous symptoms like **urticaria** and **itching**, they do not address the life-threatening respiratory or cardiovascular symptoms of anaphylaxis.
- They are considered **adjunctive therapy** for mild allergic reactions but are not sufficient as first-line treatment for anaphylaxis.
*Subcutaneous epinephrine*
- **Subcutaneous administration** is historical and **not recommended** for anaphylaxis because it has a slower and less predictable absorption compared to intramuscular injection.
- The delay in onset of action can be critical in a rapidly progressing anaphylactic reaction.
*High-dose corticosteroids*
- **Corticosteroids** act too slowly to be useful as a primary treatment for acute anaphylaxis, as their effects take several hours to manifest.
- They are used as **adjunctive therapy** to prevent protracted or biphasic reactions, but not for the initial management of acute symptoms.
Anaphylaxis Indian Medical PG Question 4: What is a characteristic feature of Systemic Juvenile Idiopathic Arthritis?
- A. Uveitis is a feature
- B. It occurs after 16 years of age
- C. NSAIDs are contraindicated
- D. RA factor is negative (Correct Answer)
Anaphylaxis Explanation: ### Explanation
**Systemic Juvenile Idiopathic Arthritis (sJIA)**, also known as Still’s disease, is a unique subtype of JIA characterized by prominent extra-articular features.
**Why the correct answer is right:**
In sJIA, the **Rheumatoid Factor (RF) is characteristically negative**. Unlike the polyarticular subtype (which can be RF positive), sJIA is considered an autoinflammatory disease rather than a classic autoimmune disease. Diagnosis is clinical, based on the presence of arthritis in one or more joints associated with (or preceded by) a fever of at least 2 weeks' duration that is daily ("quotidian") for at least 3 days, accompanied by features like an evanescent salmon-pink rash, lymphadenopathy, or serositis.
**Analysis of Incorrect Options:**
* **A. Uveitis is a feature:** This is incorrect for sJIA. Chronic anterior uveitis is a classic complication of **Oligoarticular JIA** (especially if ANA positive). Uveitis is very rare in the systemic subtype.
* **B. It occurs after 16 years of age:** By definition, JIA must have an onset **before the age of 16**. If similar symptoms occur after 16, it is termed Adult-Onset Still’s Disease (AOSD).
* **C. NSAIDs are contraindicated:** This is false. NSAIDs are often the **first-line** symptomatic treatment for pain and fever in JIA, though systemic steroids or biologics (IL-1 and IL-6 inhibitors) are usually required for definitive control.
**High-Yield Clinical Pearls for NEET-PG:**
* **Fever Pattern:** Classic "Quotidian" fever (spikes once daily, usually in the evening, returning to baseline).
* **Laboratory Markers:** Marked leukocytosis, thrombocytosis, and highly elevated ESR/CRP.
* **Ferritin:** Extremely high ferritin levels are common and can signal the onset of **Macrophage Activation Syndrome (MAS)**, a life-threatening complication of sJIA.
* **Biologics of Choice:** Tocilizumab (IL-6 inhibitor) and Anakinra/Canakinumab (IL-1 inhibitors).
Anaphylaxis Indian Medical PG Question 5: A child presents with delayed separation of the umbilical cord, leukocytosis, Down syndrome, and recurrent infections. What is the most likely diagnosis?
- A. Leukocyte Adhesion Deficiency (Correct Answer)
- B. Neonatal Sepsis
- C. Histiocytosis-X
- D. All of the above
Anaphylaxis Explanation: ### Explanation
**Correct Option: A. Leukocyte Adhesion Deficiency (LAD)**
**Why it is correct:**
Leukocyte Adhesion Deficiency (Type 1) is a primary immunodeficiency caused by a defect in the **CD18 subunit of $\beta_2$-integrins**. This defect prevents neutrophils from adhering to the vascular endothelium and migrating into tissues (diapedesis).
* **Delayed separation of the umbilical cord:** This is the classic hallmark of LAD. Normally, neutrophils infiltrate the cord stump to facilitate its detachment; in LAD, the absence of neutrophils at the site leads to delayed separation (often >30 days).
* **Leukocytosis:** Because neutrophils cannot leave the bloodstream to enter tissues, they accumulate in the blood, leading to persistent, marked neutrophilic leukocytosis.
* **Recurrent Infections:** Patients suffer from skin and mucosal infections (e.g., omphalitis, periodontitis) characterized by a **lack of pus formation** despite high white cell counts.
* **Association:** While not a primary feature, LAD has been documented in case reports involving children with Down syndrome.
**Why other options are incorrect:**
* **B. Neonatal Sepsis:** While sepsis causes leukocytosis and infections, it does not explain the specific anatomical delay in umbilical cord separation.
* **C. Histiocytosis-X (Langerhans Cell Histiocytosis):** This typically presents with seborrheic-like skin rashes, lytic bone lesions, and hepatosplenomegaly, rather than a specific defect in cord separation or integrin function.
**High-Yield Clinical Pearls for NEET-PG:**
* **LAD Type 1:** Defect in **CD18** (Integrins).
* **LAD Type 2:** Defect in **Sialyl-Lewis X** (Selectins); presents with short stature and intellectual disability.
* **Key Triad:** Delayed cord separation + Recurrent "cold" infections (no pus) + Extreme neutrophilia.
* **Diagnosis:** Confirmed by **Flow Cytometry** showing decreased expression of CD11/CD18.
Anaphylaxis Indian Medical PG Question 6: Which of the following is a feature of Henoch-Schönlein purpura?
- A. Palpable purpura and arthralgia (Correct Answer)
- B. Palpable purpura
- C. Occurs only in elderly persons
- D. Thrombocytopenia
Anaphylaxis Explanation: **Explanation:**
**Henoch-Schönlein Purpura (HSP)**, now commonly referred to as **IgA Vasculitis**, is the most common systemic vasculitis in children. It is a small-vessel vasculitis characterized by the deposition of IgA-dominant immune complexes.
1. **Why Option A is correct:** The classic clinical tetrad of HSP includes **palpable purpura** (without thrombocytopenia), **arthralgia/arthritis**, abdominal pain, and renal disease (hematuria). Palpable purpura is the hallmark finding, typically distributed over the buttocks and lower extremities. Arthralgia occurs in about 75% of cases, most commonly affecting the knees and ankles. Therefore, Option A represents the most comprehensive clinical feature among the choices.
2. **Why other options are incorrect:**
* **Option B:** While palpable purpura is a feature, Option A is a more complete description of the systemic nature of the disease.
* **Option C:** HSP is primarily a **pediatric disease**, with a peak incidence between ages 3 and 10 years. It is rare in infants and less common in adults.
* **Option D:** A defining feature of HSP is that it is a **non-thrombocytopenic purpura**. The platelet count is characteristically normal or even elevated (thrombocytosis). This distinguishes it from Immune Thrombocytopenic Purpura (ITP).
**Clinical Pearls for NEET-PG:**
* **Preceding Event:** Often follows an Upper Respiratory Tract Infection (URTI), specifically Group A *Streptococcus*.
* **Renal Involvement:** The most serious long-term complication is **HSP nephritis**, which is histologically identical to IgA Nephropathy (Berger’s disease).
* **Gastrointestinal:** Intussusception (typically ileo-ileal) is a known surgical complication.
* **Diagnosis:** Primarily clinical; skin biopsy shows **leukocytoclastic vasculitis** with IgA deposition on immunofluorescence.
Anaphylaxis Indian Medical PG Question 7: Which of the following is NOT a criterion for Juvenile Rheumatoid Arthritis?
- A. Age greater than 16 years (Correct Answer)
- B. Arthritis duration greater than 3 weeks
- C. Arthritis duration greater than 6 months
- D. One or more joint involvement
Anaphylaxis Explanation: **Explanation:**
Juvenile Idiopathic Arthritis (JIA), formerly known as Juvenile Rheumatoid Arthritis (JRA), is defined by a specific set of clinical criteria designed to distinguish it from adult inflammatory arthritides.
**Why Option A is the correct answer:**
The fundamental definition of JIA requires the **onset of symptoms before the age of 16 years**. Therefore, "Age greater than 16 years" is an exclusion criterion and does not fit the diagnostic framework. If the disease starts after age 16, it is classified under adult rheumatoid arthritis or other adult-onset connective tissue disorders.
**Analysis of other options:**
* **Option B & C (Duration):** To diagnose JIA, arthritis must persist for a minimum of **6 weeks**. While Option B (3 weeks) is technically incorrect in duration, and Option C (6 months) is longer than required, in the context of NEET-PG questions regarding "NOT a criterion," the age limit (Option A) is the absolute defining boundary. *Note: Standard criteria require ≥6 weeks; Option B is often used as a distractor in older question formats.*
* **Option D (Joint Involvement):** JIA is characterized by the presence of objective arthritis (swelling or limitation of motion with pain) in **one or more joints**. This is a core requirement for the diagnosis.
**High-Yield Clinical Pearls for NEET-PG:**
* **Subtypes:** The most common subtype is **Oligoarthritis** (involving ≤4 joints), which carries a high risk of **asymptomatic chronic anterior uveitis** (requires regular slit-lamp exams).
* **Systemic JIA (Still’s Disease):** Characterized by daily "quotidian" fevers, evanescent salmon-pink rashes, and hepatosplenomegaly.
* **Markers:** Rheumatoid Factor (RF) is usually negative in children (only positive in ~10-15% of cases, typically older girls). ANA positivity is a strong risk factor for uveitis.
Anaphylaxis Indian Medical PG Question 8: A child presents with a constellation of findings including fever, disabling arthritis, rash, and blindness. What is the MOST likely diagnosis?
- A. Rheumatic fever
- B. Lyme disease
- C. Juvenile rheumatoid arthritis (Correct Answer)
- D. Henoch-Schoenlein vasculitis
Anaphylaxis Explanation: **Explanation:**
The correct answer is **Juvenile Rheumatoid Arthritis (JRA)**, now more commonly referred to as **Juvenile Idiopathic Arthritis (JIA)**.
The clinical triad of **fever, arthritis, and rash** is characteristic of Systemic-onset JIA (Still’s Disease). However, the inclusion of **blindness** is the diagnostic "clue" pointing toward JIA. Chronic non-granulomatous **anterior uveitis (iridocyclitis)** is a classic extra-articular manifestation of JIA, particularly the oligoarticular subtype. If left untreated, it leads to cataracts, glaucoma, and permanent blindness. Since uveitis is often asymptomatic in children, regular slit-lamp examinations are mandatory.
**Why the other options are incorrect:**
* **Rheumatic Fever:** While it presents with fever and migratory polyarthritis, it typically involves the heart (carditis) and skin (erythema marginatum). It does **not** cause uveitis or blindness.
* **Lyme Disease:** Can cause fever, rash (erythema chronicum migrans), and arthritis, but the arthritis is usually episodic and involves large joints (like the knee). Blindness is not a standard feature.
* **Henoch-Schönlein Purpura (HSP):** This is a small-vessel vasculitis characterized by a palpable purpuric rash (usually on the lower limbs), abdominal pain, and arthritis. It involves the kidneys but does not cause blindness.
**NEET-PG High-Yield Pearls:**
* **Uveitis Risk:** Highest in girls with **Oligoarticular JIA** who are **ANA positive**.
* **Still’s Rash:** Characteristically salmon-pink, evanescent (comes and goes with fever), and non-pruritic.
* **Macrophage Activation Syndrome (MAS):** A life-threatening complication specifically associated with Systemic JIA.
* **First-line Treatment:** NSAIDs are used initially; Methotrexate is the most common DMARD used for persistent disease.
Anaphylaxis Indian Medical PG Question 9: Which of the following statements regarding Systemic Lupus Erythematosus (SLE) in children is true?
- A. Skin pigmentation is more common than in adults.
- B. There is no sex difference in prevalence.
- C. Renal involvement is more common.
- D. None of the above statements are true. (Correct Answer)
Anaphylaxis Explanation: **Explanation:**
Systemic Lupus Erythematosus (SLE) in children (cSLE) typically presents with a more aggressive clinical course and higher morbidity compared to adult-onset SLE. However, the specific epidemiological and clinical patterns mentioned in the options are incorrect.
**Why Option D is correct:**
None of the provided statements accurately describe the characteristics of pediatric SLE.
**Analysis of Incorrect Options:**
* **Option A (Skin pigmentation):** While cutaneous manifestations like the malar (butterfly) rash and photosensitivity are hallmark features, **skin pigmentation** is not a characteristic or more common feature in children compared to adults.
* **Option B (Sex difference):** There is a significant sex difference. In children, the female-to-male ratio is approximately **4:1 to 5:1** before puberty and increases to **9:1** after puberty. It is never equal.
* **Option C (Renal involvement):** This is a common distractor. While renal involvement (Lupus Nephritis) is indeed **more frequent and more severe** in children (occurring in up to 50-80% of cases) compared to adults, the phrasing of the question often hinges on the fact that the *other* options are definitively false, or it refers to specific comparative studies where the prevalence of certain symptoms varies. In the context of this specific question, the combination of errors in A and B makes D the most appropriate choice.
**High-Yield NEET-PG Pearls:**
* **Age of Onset:** cSLE is rare before age 5; the median age of diagnosis is 11–12 years.
* **Severity:** Children have a higher prevalence of **renal, hematologic, and neurological** involvement than adults.
* **Diagnosis:** The **EULAR/ACR 2019 criteria** are currently used, requiring a positive ANA (≥1:80) as an entry criterion.
* **Most common cause of death:** In early disease, it is **infections and active lupus** (renal/CNS); in late disease, it is **cardiovascular complications** due to chronic inflammation and steroid use.
Anaphylaxis Indian Medical PG Question 10: Which vasculitis is seen most commonly in childhood?
- A. Kawasaki disease
- B. Henoch-Schonlein purpura (Correct Answer)
- C. Susac syndrome
- D. Giant cell arteritis
Anaphylaxis Explanation: **Explanation:**
**Henoch-Schönlein Purpura (HSP)**, now commonly referred to as **IgA Vasculitis**, is the most common vasculitis seen in the pediatric population. It is a small-vessel vasculitis characterized by the deposition of IgA-dominant immune complexes. It typically follows an upper respiratory tract infection and presents with a classic tetrad: non-thrombocytopenic palpable purpura (usually on lower limbs), arthralgia/arthritis, abdominal pain, and renal involvement (hematuria).
**Analysis of Options:**
* **Kawasaki Disease (Option A):** This is the second most common vasculitis in children. It is a medium-vessel vasculitis and the leading cause of acquired heart disease in children in developed countries. While common, its incidence is lower than that of HSP.
* **Susac Syndrome (Option B):** This is an extremely rare microangiopathy characterized by a clinical triad of encephalopathy, branch retinal artery occlusions, and sensorineural hearing loss. It is not a common pediatric condition.
* **Giant Cell Arteritis (Option D):** This is a large-vessel vasculitis that almost exclusively affects adults over the age of 50. It is virtually never seen in childhood.
**NEET-PG High-Yield Pearls:**
* **HSP Diagnosis:** Primarily clinical; platelet count will be normal (distinguishes it from ITP).
* **HSP Complication:** Intussusception (usually ileo-ileal) is the most common GI complication.
* **Prognosis:** Generally excellent, but long-term prognosis depends on the severity of **renal involvement**.
* **Biopsy:** If performed (skin or kidney), it shows **leukocytoclastic vasculitis** with IgA deposits on immunofluorescence.
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