Autism Spectrum Disorders

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ASD Unveiled - Spectrum Secrets

  • Neurodevelopmental: Deficits in social communication/interaction & Restricted, Repetitive Behaviors (RRBs).
  • DSM-5 Snapshot:
    • A: Social communication/interaction deficits (reciprocity, nonverbal, relationships).
    • B: ≥2 RRBs (stereotypies, sameness, fixated interests, sensory issues).
    • C: Early onset; D: Significant impairment.
  • Prevalence: ~1 in 100 (WHO); India: ~1 in 68. M:F ~4:1.
  • Etiology:
    • Genetic: High heritability (~80%); polygenic. Syndromic: Fragile X.
    • Environmental: Advanced parental age, prenatal valproate. ⚠️ No vaccine link.
  • Key Signs:
    • Social: ↓ eye contact, ↓ joint attention.
    • Communication: Delayed speech, echolalia.
    • Behavior: Stereotypies, routines, sensory issues.
  • Screening: M-CHAT-R/F (18 & 24 months).

⭐ Red flags: No babbling/pointing by 12 mo, no single words by 16 mo, no 2-word spontaneous phrases by 24 mo.

ASD 2 main areas of impairment

Red Flags & Features - Spotting ASD

📌 SCR - Core Symptom Domains:

  • Social-emotional reciprocity:
    • Impaired joint attention, abnormal social approach.
  • Communication (verbal & non-verbal):
    • Delayed speech, poor gesture/eye contact use.
  • Restricted, Repetitive Behaviors (RRBs):
    • Stereotyped movements, insistence on sameness, fixated interests.

Developmental Red Flags:

  • No babbling by 12 months.
  • No pointing/other gestures by 12 months.
  • No single words by 16 months.
  • No 2-word spontaneous phrases (not just echolalia) by 24 months.
  • ⚠️ ANY loss of language/social skills at ANY age.

Early signs of Autism in preschool children

Co-occurring:

  • Intellectual Disability
  • ADHD
  • Anxiety, Epilepsy
  • Sleep/GI issues

⭐ Regression of milestones (language/social skills) after normal development is a major red flag for ASD evaluation.

Pinpointing ASD - Confirming Clues

  • Screening: Universal at 18 & 24 months.
    • M-CHAT-R/F: Score 3-7 → Follow-up interview. Score ≥8 → Refer for diagnostic evaluation.
  • Comprehensive Diagnostic Evaluation:
    • Detailed history (developmental, medical, family).
    • Standardized tools: ADOS-2 (observation), ADI-R (interview).
    • Multidisciplinary assessment: cognition, language, adaptive behavior.
  • Diagnosis: Based on DSM-5 criteria (persistent social communication deficits & restricted, repetitive behaviors/interests - RRBs).
  • Differential Diagnoses: Global Developmental Delay, Intellectual Disability, Language Disorders, ADHD, Anxiety, Rett Syndrome.

⭐ M-CHAT-R/F: A score of 0-2 is low risk; 3-7 is medium risk (administer Follow-Up); 8-20 is high risk (refer for diagnosis & eligibility evaluation).

Intervention Roadmap - Supportive Steps

  • Early Intervention: Critical for optimal outcomes; initiate as soon as ASD is suspected.
  • Multidisciplinary Team: Pediatrician, psychiatrist, psychologist, speech therapist, occupational therapist, special educator.
    • Behavioral: Applied Behavior Analysis (ABA), structured teaching (TEACCH).
    • Educational: Individualized Education Programs (IEPs).
    • Speech & Language Therapy: Address communication deficits.
    • Occupational Therapy: Improve sensory integration, daily living skills.
  • Family Support & Training: Essential for consistency and generalization of skills.
  • Pharmacotherapy: For co-occurring conditions (e.g., ADHD, anxiety, irritability); Risperidone/Aripiprazole for irritability.

⭐ Early intensive behavioral intervention (EIBI), particularly ABA, is the most evidence-based treatment for improving core ASD symptoms.

High‑Yield Points - ⚡ Biggest Takeaways

  • Core deficits: Persistent difficulties in social communication and social interaction.
  • Behavioral patterns: Restricted, repetitive behaviors (RRBs), fixated interests, or activities.
  • Early onset: Symptoms manifest in early developmental period, typically before age 3.
  • Screening: M-CHAT-R/F is a widely used screening tool for toddlers (at 18 & 24 months).
  • Etiology: Complex neurodevelopmental disorder with strong genetic predisposition; multifactorial.
  • Management: Early intensive behavioral intervention (e.g., ABA) is the cornerstone of treatment.
  • Common Co-occurrences: Intellectual disability, ADHD, anxiety disorders, and epilepsy.

Practice Questions: Autism Spectrum Disorders

Test your understanding with these related questions

A 3-year-old child with delayed speech development, prefers to play alone and is not making friends. The likely diagnosis is

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Flashcards: Autism Spectrum Disorders

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At _____ months, make-believe (symbolic) play centers on the child s own body

TAP TO REVEAL ANSWER

At _____ months, make-believe (symbolic) play centers on the child s own body

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